Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of
a number of diseases and conditions. Oxidative stress occurs once the antioxidant defenses …

The brain uses long-chain fatty acids (LCFAs) to a negligible extent as fuel for the
mitochondrial energy generation, in contrast to other tissues that also demand high energy …

The activation of the highly conserved unfolded protein response (UPR) is prominent in the
pathogenesis of the most prevalent neurodegenerative disorders, such as Alzheimer's …

Mitochondrial dysfunctions and oxidative stress are involved in several non demyelinating or
demyelinating neurodegenerative diseases. Some of them, including multiple sclerosis …

Leukodystrophies are serious, progressive, genetic disorders of CNS myelin. They may
result from abnormalities of the oligodendrocyte or any of the other of myriad of supporting …

Objective: Skin amyloid deposits can occur as part of systemic amyloidoses including those
involving misfolded-aggregated transthyretins (agTTR). Pathological effects of agTTR on the …

Introduction: Recent evidence shows that oxidative stress seems to be related with the
pathophysiology of X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder …