Congenital central hypoventilation syndrome: a bedside-to-bench success story for advancing early diagnosis and treatment and improved survival and quality of life
Abstract The “bedside-to-bench” Congenital Central Hypoventilation Syndrome (CCHS)
research journey has led to increased phenotypic-genotypic knowledge regarding …
research journey has led to increased phenotypic-genotypic knowledge regarding …
Non‐chemosensitive parafacial neurons simultaneously regulate active expiration and airway patency under hypercapnia in rats
AA de Britto, DJA Moraes - The Journal of Physiology, 2017 - Wiley Online Library
Key points Hypercapnia or parafacial respiratory group (pFRG) disinhibition at normocapnia
evokes active expiration in rats by recruitment of pFRG late‐expiratory (late‐E) neurons. We …
evokes active expiration in rats by recruitment of pFRG late‐expiratory (late‐E) neurons. We …
Role of the locus coeruleus catecholaminergic neurons in the chemosensory control of breathing in a Parkinson's disease model
LM Oliveira, M Tuppy, TS Moreira, AC Takakura - Experimental neurology, 2017 - Elsevier
A previous study has demonstrated that in the 6-hydroxydopamine (6-OHDA)-model of
Parkinson's disease (PD) there is a reduction in the number of Phox2b neurons in the …
Parkinson's disease (PD) there is a reduction in the number of Phox2b neurons in the …
Cardiovascular dysfunction associated with neurodegeneration in an experimental model of Parkinson's disease
Patients with Parkinson's disease (PD) exhibit both motor and non-motor symptoms. Among
the non-motor symptoms, cardiovascular autonomic dysfunction is frequently observed …
the non-motor symptoms, cardiovascular autonomic dysfunction is frequently observed …
Depletion of rostral ventrolateral medullary catecholaminergic neurons impairs the hypoxic ventilatory response in conscious rats
The stimuli that commonly activate the catecholaminergic C1 neurons (nociception,
hypotension, and hypoxia) also increase breathing. Pharmacogenetic evidence suggests …
hypotension, and hypoxia) also increase breathing. Pharmacogenetic evidence suggests …
Fluorocitrate-mediated depolarization of astrocytes in the retrotrapezoid nucleus stimulates breathing
CR Sobrinho, CM Gonçalves… - Journal of …, 2017 - journals.physiology.org
Evidence indicates that CO2/H+-evoked ATP released from retrotrapezoid nucleus (RTN)
astrocytes modulates the activity of CO2-sensitive neurons. RTN astrocytes also sense H+ …
astrocytes modulates the activity of CO2-sensitive neurons. RTN astrocytes also sense H+ …
Impaired central respiratory chemoreflex in an experimental genetic model of epilepsy
LT Totola, AC Takakura, JAC Oliveira… - The Journal of …, 2017 - Wiley Online Library
Key points It is recognized that seizures commonly cause apnoea and oxygen desaturation,
but there is still a lack in the literature about the respiratory impairments observed ictally and …
but there is still a lack in the literature about the respiratory impairments observed ictally and …
Neurodevelopmental effects of serotonin on the brainstem respiratory network
K Bravo, J Eugenín, I Llona - The Plastic Brain, 2017 - Springer
Serotonin has multiple roles during development of the nervous system. Human
pathologies, mouse genetic models, and pharmacological experiments have demonstrated …
pathologies, mouse genetic models, and pharmacological experiments have demonstrated …
The Hypercapnic Ventilatory Response and Behavior in Ca2+-Activated K+ (BK) Channel Knock Out Mice And T-Cell Death-Associated Gene 8 (TDAG8) Receptor …
CA Ratliff-Rang - 2017 - corescholar.libraries.wright.edu
Some acid sensing areas in the brain control the expression of breathing and anxiety/fear
including the locus coeruleus (LC)(Redmond & Huang, 1979) and the nucleus tractus …
including the locus coeruleus (LC)(Redmond & Huang, 1979) and the nucleus tractus …