Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …

Synchronous release triggered by Ca 2+ binding to synaptotagmin-1,-2, or-9 is thought to
drive fast synaptic transmission, whereas asynchronous release induced by Ca 2+ binding …

Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-
priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how …

Neural information processing depends on precisely timed, Ca 2+-activated synaptic vesicle
exocytosis from release sites within active zones (AZs), but molecular details are unknown …

Munc13 proteins are essential regulators of neurotransmitter release at nerve cell synapses.
They mediate the priming step that renders synaptic vesicles fusion-competent, and their …

The presynaptic active zone protein Munc13 is essential for neurotransmitter release,
playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A …

The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools that
are differentially poised for exocytosis shapes short-term plasticity. However, the frequency …

Presynaptic active zones (AZs) are unique subcellular structures at neuronal synapses,
which contain a network of specific proteins that control synaptic vesicle (SV) tethering …

Munc13-4 is a Ca2+-dependent SNARE (soluble N-ethylmaleimide–sensitive factor
attachment protein receptor)-and phospholipid-binding protein that localizes to and primes …

Chronic exposure to alcohol produces adaptations within the basolateral amygdala (BLA)
that are associated with the development of anxiety-like behaviors during withdrawal. In part …