[HTML][HTML] Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18
Y Lai, UB Choi, J Leitz, HJ Rhee, C Lee, B Altas… - Neuron, 2017 - cell.com
Munc13 catalyzes the transit of syntaxin from a closed complex with Munc18 into the ternary
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …
SNARE complex. Here we report a new function of Munc13, independent of Munc18: it …
[HTML][HTML] Synaptotagmin-7-mediated asynchronous release boosts high-fidelity synchronous transmission at a central synapse
F Luo, TC Südhof - Neuron, 2017 - cell.com
Synchronous release triggered by Ca 2+ binding to synaptotagmin-1,-2, or-9 is thought to
drive fast synaptic transmission, whereas asynchronous release induced by Ca 2+ binding …
drive fast synaptic transmission, whereas asynchronous release induced by Ca 2+ binding …
[HTML][HTML] Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN
Munc13–1 acts as a master regulator of neurotransmitter release, mediating docking-
priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how …
priming of synaptic vesicles and diverse presynaptic plasticity processes. It is unclear how …
[HTML][HTML] Stable positioning of Unc13 restricts synaptic vesicle fusion to defined release sites to promote synchronous neurotransmission
S Reddy-Alla, MA Böhme, E Reynolds, C Beis… - Neuron, 2017 - cell.com
Neural information processing depends on precisely timed, Ca 2+-activated synaptic vesicle
exocytosis from release sites within active zones (AZs), but molecular details are unknown …
exocytosis from release sites within active zones (AZs), but molecular details are unknown …
[HTML][HTML] Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder
N Lipstein, NM Verhoeven-Duif… - The Journal of …, 2017 - Am Soc Clin Investig
Munc13 proteins are essential regulators of neurotransmitter release at nerve cell synapses.
They mediate the priming step that renders synaptic vesicles fusion-competent, and their …
They mediate the priming step that renders synaptic vesicles fusion-competent, and their …
[HTML][HTML] Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming
The presynaptic active zone protein Munc13 is essential for neurotransmitter release,
playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A …
playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A …
[HTML][HTML] Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity
F Doussau, H Schmidt, K Dorgans, AM Valera… - Elife, 2017 - elifesciences.org
The segregation of the readily releasable pool of synaptic vesicles (RRP) in sub-pools that
are differentially poised for exocytosis shapes short-term plasticity. However, the frequency …
are differentially poised for exocytosis shapes short-term plasticity. However, the frequency …
ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones
H Kawabe, M Mitkovski, PS Kaeser, J Hirrlinger… - Journal of Cell …, 2017 - rupress.org
Presynaptic active zones (AZs) are unique subcellular structures at neuronal synapses,
which contain a network of specific proteins that control synaptic vesicle (SV) tethering …
which contain a network of specific proteins that control synaptic vesicle (SV) tethering …
Munc13-4 functions as a Ca2+ sensor for homotypic secretory granule fusion to generate endosomal exocytic vacuoles
SS Woo, DJ James, TFJ Martin - Molecular biology of the cell, 2017 - Am Soc Cell Biol
Munc13-4 is a Ca2+-dependent SNARE (soluble N-ethylmaleimide–sensitive factor
attachment protein receptor)-and phospholipid-binding protein that localizes to and primes …
attachment protein receptor)-and phospholipid-binding protein that localizes to and primes …
[HTML][HTML] Ethanol mediated inhibition of synaptic vesicle recycling at amygdala glutamate synapses is dependent upon Munc13-2
DA Gioia, N Alexander, BA McCool - Frontiers in neuroscience, 2017 - frontiersin.org
Chronic exposure to alcohol produces adaptations within the basolateral amygdala (BLA)
that are associated with the development of anxiety-like behaviors during withdrawal. In part …
that are associated with the development of anxiety-like behaviors during withdrawal. In part …