Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

The most common cause of untreatable vision loss is dysfunction of the retina. Conditions,
such as age-related macular degeneration, diabetic retinopathy and glaucoma remain …

Diabetes mellitus is a complex systemic disease characterized by severe morbidity and
excess mortality. The burden of its multiorgan complications relies on an imbalance between …

Mesenchymal stem cells derived from bone marrow (BM-MSCs) have multifunctional
properties that have made them a promising therapeutic agent for many regenerative, anti …

Diabetic retinopathy (DR) is a complication secondary to diabetes and is the number one
cause of blindness among working age individuals worldwide. Despite recent therapeutic …

Many of the physiological, cellular, and molecular rhythms that are present within the eye
are under the control of circadian clocks. Experimental evidence suggests that the retinal …

The brain and muscle aryl hydrocarbon receptor nuclear translocator–like protein (BMAL)-1
constitutes a major transcriptional regulator of the circadian clock. Here, we explored the …

Background & Objective: Bone defects caused by bone fractures, malformations,
postoperation on tumor and even periodontitis have became serious clinical problems …

Purpose: We investigated the relationship between inflammation, neuronal loss, and
expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the retina of …

Background Diabetes mellitus is a risk factor for coronary artery disease and diabetic
cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting …