Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection
of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the …

Abstract Purpose of the Review Type 1 diabetes (T1D) is defined by an autoimmune
destruction of insulin producing β-cells located in the endocrine part of the pancreas, the …

Replacing defective retinal pigment epithelial (RPE) cells with those derived from human
embryonic stem cells (hESCs) or human-induced pluripotent stem cells (hiPSCs) is a …

Background Human embryonic stem cells (hESCs) hold tremendous promise for cell
replacement therapies for a range of degenerative diseases. In order to provide cost …

Disease or trauma-induced loss or dysfunction of neurons in any central nervous system
(CNS) tissue will have a significant impact on the health of the affected patient. The retina is …

Pluripotent parthenogenetic stem cells (pSCs) can be derived by pharmacological activation
of unfertilized oocytes. Homozygosity of the major histocompatibility complex (MHC) in pSCs …

Background and purpose: The unique characteristics and potency of stem cells have
attracted interest for their use in cell therapy. However, the use of these cells has some …

While other cell-based therapies for ischemic heart disease are generally understood to
operate through indirect, so-called “paracrine” mechanisms of action (eg, by promoting …

The perspective to transplant grafts derived from pluripotent stem cells has gained much
attention in recent years. Parthenogenetic stem cells (PSCs) are an alternative pluripotent …

Cell therapy has the potential to treat a wide variety of unmet therapeutic indications that
affect a growing number of people globally. Many of these therapies require purification …