T cells are considered pivotal in the pathology of multiple sclerosis (MS), but their function
and antigen specificity are unknown. To unravel the role of T cells in MS pathology, we …

Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …

Disruption of the blood–brain barrier (BBB) is a defining and early feature of multiple
sclerosis (MS) that directly damages the central nervous system (CNS), promotes immune …

Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule found on
blood–brain barrier endothelial cells (BBB-ECs) that was previously shown to be involved in …

The lymphatic network linking the CNS to draining lymph nodes may contribute to the
inflammatory reaction occurring in multiple sclerosis (MS). The abundance and strategic …

Objective: Lymphopenia is a common occurrence of disease-modifying therapies (DMTs) for
relapsing-remitting MS (RRMS). The aim of this study was to dissect the prevalence of …

Paraneoplastic neurological disorders (PNDs) are rare human autoimmune diseases that
mostly affect the central nervous system (CNS). They are triggered by an efficient immune …

With the increasing proportion of the global geriatric population, it becomes obvious that
neurodegenerative diseases will become more widespread. From an epidemiological …

Multiple physiological mechanisms exist to protect the brain from immunemediated neuronal
damage 150. However, these same protective mechanisms make it challenging to tease …

Prior focus has largely been on the role of CD4+ T cells in Multiple sclerosis (MS) disease
pathogenesis, but there is mounting evidence for the role of CD8+ T cells. This thesis aimed …