[HTML][HTML] Transcribing β-cell mitochondria in health and disease
H Mulder - Molecular metabolism, 2017 - Elsevier
Background The recent genome-wide association studies (GWAS) of Type 2 Diabetes (T2D)
have identified the pancreatic β-cell as the culprit in the pathogenesis of the disease …
have identified the pancreatic β-cell as the culprit in the pathogenesis of the disease …
[HTML][HTML] The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases
The Metabolic Syndrome in Men (METSIM) study is a population-based study including
10,197 Finnish men examined in 2005–2010. The aim of the study is to investigate …
10,197 Finnish men examined in 2005–2010. The aim of the study is to investigate …
[HTML][HTML] HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells
Aims/hypothesis Pancreatic beta cell dysfunction is a prerequisite for the development of
type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic endocrine function …
type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic endocrine function …
Roles of mitochondrial DNA in energy metabolism
J Lv, M Bhatia, X Wang - Mitochondrial DNA and Diseases, 2017 - Springer
Mitochondria are independent double-membrane organelles responsible for energy
production, specifically by completing oxidative phosphorylation. Mitochondria are essential …
production, specifically by completing oxidative phosphorylation. Mitochondria are essential …
[HTML][HTML] Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells
Objective Insulin release from pancreatic β-cells is controlled by plasma glucose levels via
mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on …
mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on …
Perturbed mitochondrial metabolism in islets from donors with type-2 diabetes
There is a preponderance for genes involved in ß-cell function among gene variants
associated with future risk of type-2 diabetes (T2D). ß-cell function is controlled by …
associated with future risk of type-2 diabetes (T2D). ß-cell function is controlled by …
Divergent functions of a ribosome maturation factor
N Desai - Biotarget, 2017 - biotarget.amegroups.org
The ribosome, the large macromolecular complex responsible for the translation of
messenger RNA (mRNA) into proteins, must be matured and assembled correctly for …
messenger RNA (mRNA) into proteins, must be matured and assembled correctly for …