Epstein–Barr virus (EBV) is associated with multiple types of human cancer, including
lymphoid and epithelial cancers. The closest association with EBV infection is seen in …

Recent clinical trials have demonstrated that the immense majority of acute promyelocytic
leukemia (APL) patients can be definitively cured by the combination of two targeted …

SUMOylation modifies the interactome, localization, activity, and lifespan of its target
proteins. This process regulates several cellular machineries, including transcription, DNA …

Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER–
mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to …

The tumor microenvironment plays an important role in tumor growth and metastasis.
However, the mechanism by which tumor cells regulate the cell and non-cell constituents of …

Cell migration through the brain parenchyma underpins neurogenesis and glioblastoma
(GBM) development. Since GBM cells and neuroblasts use the same migratory routes …

Accumulating evidence has defined nucleophosmin 1 (NPM1) mutation as a driver genetic
event in acute myeloid leukemia (AML), whereas the pathogenesis of NPM1-mutated AML …

IFNs are effective in inhibiting angiogenesis in preclinical models and in treating several
angioproliferative disorders. However, the detailed mechanisms of IFNα-mediated anti …

The promyelocytic leukemia protein (PML) is expressed in most normal human tissues and
forms nuclear bodies (NBs) that have roles in gene regulation and cellular processes such …

Significance: Cellular metabolic activity impacts the production of reactive oxygen species
(ROS), both positively through mitochondrial oxidative processes and negatively by …