The rapid development of next generation sequencing technology has greatly increased the
amount of available microbial genomes. As a result of this development, there is a rising …

Abstract Model microbial systems provide opportunity to understand the genetic bases of
ecological traits, their evolution, regulation and fitness contributions. Experimental …

Flavobacterium columnare is a Gram-negative fish pathogen causing columnaris disease in
wild and cultured fish species. Although the pathogen is widespread in aquatic …

Ca2+ plays an important role in the physiology of bacteria. Intracellular Ca2+ concentrations
are tightly maintained in the nanomolar range. Molecular mechanisms of Ca2+ uptake in …

Background Utilising next generation sequencing to interrogate saturated bacterial mutant
libraries provides unprecedented information for the assignment of genome-wide gene …

Abstract Knowledge of adaptive processes encompasses understanding the emergence of
new genes. Computational analyses of genomes suggest that new genes can arise by …

Microbial communities may now be studied in more detail using culture-independent
methods such as metagenomics (directly analyzing genomes from an environmental …

The massive increase in health-related digital data has revolutionized the power of machine
learning algorithms to produce more salient information. Digital health data consists of …

Background: Among the four bases, guanine is the most susceptible to damage from
oxidative stress. Replication of DNA containing damaged guanines result in G to T …

In comparative genomics, orthologs are desired to be detected accurately. If right orthologs
are detected, then they could predict the function of newly sequenced genes. These genes …