[HTML][HTML] Ovarian cancer stem cells: still an elusive entity?
M Lupia, U Cavallaro - Molecular Cancer, 2017 - Springer
The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …
Challenges and opportunities in studying the epidemiology of ovarian cancer subtypes
Abstract Purpose of Review Only recently has it become clear that epithelial ovarian cancer
(EOC) is comprised of such distinct histotypes—with different cells of origin, morphology …
(EOC) is comprised of such distinct histotypes—with different cells of origin, morphology …
[HTML][HTML] CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors
Effective targeting of cancer stem cells (CSCs) requires neutralization of self-renewal and
chemoresistance, but these phenotypes are often regulated by distinct molecular …
chemoresistance, but these phenotypes are often regulated by distinct molecular …
[HTML][HTML] NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity
Q Li, X Liu, K Jin, M Lu, C Zhang, X Du, B Xing - BMc cancer, 2017 - Springer
Abstract Background N-acetyltransferase 10 (NAT10) is a histone acetyltransferase which is
involved in a wide range of cellular processes. Recent evidences indicate that NAT10 is …
involved in a wide range of cellular processes. Recent evidences indicate that NAT10 is …
Profiling cytidine acetylation with specific affinity and reactivity
WR Sinclair, D Arango, JH Shrimp… - ACS chemical …, 2017 - ACS Publications
The human acetyltransferase NAT10 has recently been shown to catalyze formation of N4-
acetylcytidine (ac4C), a minor nucleobase known to alter RNA structure and function. In …
acetylcytidine (ac4C), a minor nucleobase known to alter RNA structure and function. In …
[HTML][HTML] Update on immune checkpoint inhibitors in gynecological cancers
V Heong, N Ngoi, DSP Tan - Journal of Gynecologic Oncology, 2017 - ncbi.nlm.nih.gov
In recent years, progress in our understanding of immune-modulatory signaling pathways in
immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in …
immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in …
Autoacetylation of NAT10 is critical for its function in rRNA transcription activation
S Cai, X Liu, C Zhang, B Xing, X Du - Biochemical and biophysical …, 2017 - Elsevier
NAT10, an important member of GNAT family, harbors histone acetyltransferase and
participates in many cellular processes such as ribosome production and cell cycle. Here …
participates in many cellular processes such as ribosome production and cell cycle. Here …
Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma
(HCC), yet little is known about the molecular pathology associated with this factor. In this …
(HCC), yet little is known about the molecular pathology associated with this factor. In this …
Integrated analysis reveals tubal-and ovarian-originated serous ovarian cancer and predicts differential therapeutic responses
Purpose: The relative importance of fallopian tube (FT) compared with ovarian surface
epithelium (OSE) in the genesis of serous type of ovarian cancer (SOC) is still unsettled …
epithelium (OSE) in the genesis of serous type of ovarian cancer (SOC) is still unsettled …
[HTML][HTML] The prognostic 97 chemoresponse gene signature in ovarian cancer
Patient diagnosis and care would be significantly improved by understanding the
mechanisms underlying platinum and taxane resistance in ovarian cancer. Here, we aim to …
mechanisms underlying platinum and taxane resistance in ovarian cancer. Here, we aim to …