Nanodrug delivery systems for targeting the endogenous tumor microenvironment and simultaneously overcoming multidrug resistance properties

R Li, Y Xie - Journal of Controlled Release, 2017 - Elsevier
Multidrug resistance (MDR) is a major obstacle to successful cancer therapy, especially for
chemotherapy. Endogenous stimulus-responsive nanosystems (ESRNs), which were …

Spatio-temporal control strategy of drug delivery systems based nano structures

N Rahoui, B Jiang, N Taloub, YD Huang - Journal of Controlled Release, 2017 - Elsevier
The drug instability, toxicity and the barrier to the target area necessitate a suitable drug
delivery system with an external or internal control of the release. Spatio-temporal control …

Redox and pH dual responsive polymer based nanoparticles for in vivo drug delivery

CY Ang, SY Tan, C Teh, JM Lee, MFE Wong, Q Qu… - Small, 2017 - Wiley Online Library
Responsive nanomaterials have emerged as promising candidates as drug delivery
vehicles in order to address biomedical diseases such as cancer. In this work, polymer …

pH‐triggered pinpointed cascading charge‐conversion and redox‐controlled gene release design: modularized fabrication for nonviral gene transfection

Q Jiang, Y Nie, X Chen, Y He, D Yue… - Advanced Functional …, 2017 - Wiley Online Library
Although pH and reduction responses are widely applied on gene and drug delivery system,
the undefined molecule and disconnected response to corresponding transfection barriers …

pH/redox dual-sensitive dextran nanogels for enhanced intracellular drug delivery

M Curcio, L Diaz-Gomez, G Cirillo, A Concheiro… - European Journal of …, 2017 - Elsevier
Abstract pH/redox dual-responsive nanogels (DEX-SS) were prepared by precipitation
polymerization of methacrylated dextran (DEXMA), 2-aminoethylmethacrylate (AEMA) and …

A Target‐Directed Chemo‐Photothermal System Based on Transferrin and Copolymer‐Modified MoS2 Nanoplates with pH‐Activated Drug Release

A Zhang, A Li, W Tian, Z Li, C Wei, Y Sun… - … A European Journal, 2017 - Wiley Online Library
Molybdenum disulfide (MoS2) nanosheets have attracted significant attention due to their
photothermal properties, but the poor solubility and colloidal stability limited their further …

A dual pH-and reduction-responsive anticancer drug delivery system based on PEG–SS–poly (amino acid) block copolymer

B Li, M Shan, X Di, C Gong, L Zhang, Y Wang, G Wu - RSC advances, 2017 - pubs.rsc.org
A pH-and reduction-responsive anticancer drug delivery system was prepared and the
triggerable and controllable drug release in response to stimuli was observed. In the first …

Tunable pH and redox-responsive drug release from curcumin conjugated γ-polyglutamic acid nanoparticles in cancer microenvironment

S Pillarisetti, S Maya, S Sathianarayanan… - Colloids and Surfaces B …, 2017 - Elsevier
Tunable pH and redox responsive polymer was prepared using γ-polyglutamic acid (γ-PGA)
with linker 3-mercaptopropionic acid (3-MPA)(γ-PGA_SH) via oxidation to obtain redox …

Chitosan based nanogels stepwise response to intracellular delivery kinetics for enhanced delivery of doxorubicin

Y Zuo, M Kong, Y Mu, C Feng, X Chen - International Journal of Biological …, 2017 - Elsevier
Chitosan based nanogels with pH/redox sensitivities tunable to stepwise response to
intracellular delivery kinetics were developed. The nanogels were simply constructed by …

Targeted nanotechnologies for cancer intervention: a patent review (2010-2016)

P Pradeep, P Kumar, YE Choonara… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: In recent years, several active targeting nanostrategies have been patented for
application in cancer theranostics. The versatility of nanostructures in terms of composition …