Heart failure in pediatric patients with congenital heart disease

RB Hinton, SM Ware - Circulation research, 2017 - Am Heart Assoc
Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and
secondary causes and shared pathways of disease progression, correlating with substantial …

[HTML][HTML] Ebstein's anomaly: genetics, clinical manifestations, and management

SM Yuan - Pediatrics & Neonatology, 2017 - Elsevier
Ebstein's anomaly is uncommon. Genetic bases of this congenital heart defect may be
related to the mutations in myosin heavy chain 7 and NKX2. 5, among others. Asymptomatic …

The changing epidemiology of Ebstein's anomaly and its relationship with maternal mental health conditions: a European registry-based study

B Boyle, E Garne, M Loane, MC Addor… - Cardiology in the …, 2017 - cambridge.org
ObjectivesThe aim of this study was to describe the epidemiology of Ebstein's anomaly in
Europe and its association with maternal health and medication exposure during pregnancy …

Recent advancements in the molecular genetics of left ventricular noncompaction cardiomyopathy

X Dong, P Fan, T Tian, Y Yang, Y Xiao, K Yang, Y Liu… - Clinica Chimica …, 2017 - Elsevier
Left ventricular noncompaction cardiomyopathy (LVNC) is a myocardial disorder
characterized by prominent and excessive trabeculations with deep recesses in the …

Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO

DA Scott, A Hernandez-Garcia, MS Azamian… - Journal of medical …, 2017 - jmg.bmj.com
Background The non-POU domain containing octamer-binding gene (NONO) is located on
chromosome Xq13. 1 and encodes a member of a small family of RNA-binding and DNA …

[HTML][HTML] A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects

IHM Van der Linde, YL Hiemstra, R Bökenkamp… - Netherlands Heart …, 2017 - Springer
Background Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause
cardiomyopathy but are less frequently associated with congenital heart defects. Methods In …

Is left ventricular noncompaction a trait, phenotype, or disease? The evidence points to phenotype

RE Hershberger, A Morales… - Circulation: Cardiovascular …, 2017 - Am Heart Assoc
2 Hershberger et al Left Ventricular Noncompaction 1480 individuals from the UK-Canadian
TASCFORCE study (Tayside Screening for Cardiac Events), also identified LVNC as a …

Familial Ebstein Anomaly: Whole Exome Sequencing Identifies Novel Phenotype Associated With FLNA

CL Mercer, G Andreoletti, A Carroll… - Circulation …, 2017 - Am Heart Assoc
Background—Familial Ebstein anomaly is a rare form of congenital heart disease. We report
7 individuals among 2 generations of 1 family with Ebstein anomaly. This family was first …

Origins and consequences of congenital heart defects affecting the right ventricle

OI Woudstra, S Ahuja, JP Bokma… - Cardiovascular …, 2017 - academic.oup.com
Congenital heart disease is a major health issue, accounting for a third of all congenital
defects. Improved early surgical management has led to a growing population of adults with …

[HTML][HTML] Copy number variants in Ebstein anomaly

A Giannakou, RJ Sicko, W Zhang, P Romitti… - PLoS …, 2017 - journals.plos.org
Background Ebstein anomaly (EA) is a rare congenital defect characterized by apical
displacement of the septal tricuspid leaflets and atrialization of the right ventricle. The …