In addition to regulating immune responses, the NF-κB family of transcription factors also
promotes cellular proliferation and survival. NF-κB and its activating kinase, IKK, have …

The nuclear factor (NF)-κB essential modulator (NEMO) is a key regulator in NF-κB-
mediated signaling. By transmitting extracellular or intracellular signals, NEMO can control …

DNA damage is a vital challenge to cell homeostasis. Cellular responses to DNA damage
(DDR) play essential roles in maintaining genomic stability and survival, whose failure could …

Cells and tissues are exposed to stress from numerous sources. Senescence is a protective
mechanism that prevents malignant tissue changes and constitutes a fundamental …

T-cell memory is critical for long-term immunity. However, the factors involved in maintaining
the persistence, function, and phenotype of the memory pool are undefined. Eomesodermin …

Reed-Sternberg (RS) cells of classical Hodgkin lymphoma (cHL) express multiple
immunoregulatory proteins that shape the cHL microenvironment and allow tumor cells to …

Abstract Myeloid differentiation protein 2 (MD-2) is required in the recognition of
lipopolysaccharide (LPS) by toll-like receptor 4 (TLR4), and participates in LPS-induced …

NPM1/nucleophosmin is frequently overexpressed in various tumors, although the
oncogenic role of NPM1 remains unclear. Here we revealed the link between NPM1 and …

Background Oxidized low-density lipoprotein (oxLDL) mediates the transformation of
macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory …

Melanoma differentiation‐associated protein 5 (MDA 5) mediates the innate immune
response to viral infection. Polymorphisms in IFIH1, the gene coding for MDA 5, correlate …