Dendritic cells in cancer: the role revisited
F Veglia, DI Gabrilovich - Current opinion in immunology, 2017 - Elsevier
Highlights•All major subsets of DCs are critical component of anti-tumor immunity.•DCs in
TME show defects in differentiation, activation and functions.•The presence inf-DCs with anti …
TME show defects in differentiation, activation and functions.•The presence inf-DCs with anti …
[HTML][HTML] Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy
AR Sánchez-Paulete, A Teijeira, FJ Cueto, S Garasa… - Annals of …, 2017 - Elsevier
Dendritic cells (DCs) are the main professional antigen-presenting cells for induction of T-
cell adaptive responses. Cancer cells express tumor antigens, including neoantigens …
cell adaptive responses. Cancer cells express tumor antigens, including neoantigens …
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
AC Villani, R Satija, G Reynolds, S Sarkizova… - Science, 2017 - science.org
INTRODUCTION Dendritic cells (DCs) and monocytes consist of multiple specialized
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen …
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen …
Mapping the human DC lineage through the integration of high-dimensional techniques
INTRODUCTION Dendritic cells (DC) are professional antigen-presenting cells that
orchestrate immune responses. The human DC population comprises multiple subsets …
orchestrate immune responses. The human DC population comprises multiple subsets …
Dendritic cells display subset and tissue-specific maturation dynamics over human life
T Granot, T Senda, DJ Carpenter, N Matsuoka… - Immunity, 2017 - cell.com
Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in
conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our …
conventional dendritic cell (cDC) biology but remains poorly defined in humans. Using our …
[HTML][HTML] Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues
Our understanding of conventional dendritic cell (cDC) development and the functional
specializations of distinct subsets in the peripheral tissues has increased greatly in recent …
specializations of distinct subsets in the peripheral tissues has increased greatly in recent …
Intratumoral delivery of immunotherapy—act locally, think globally
Immune mechanisms have evolved to cope with local entry of microbes acting in a confined
fashion but eventually inducing systemic immune memory. Indeed, in situ delivery of a …
fashion but eventually inducing systemic immune memory. Indeed, in situ delivery of a …
[HTML][HTML] Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy
During the last decades, the pleiotropic antitumor functions exerted by type I interferons
(IFNs) have become universally acknowledged, especially their role in mediating …
(IFNs) have become universally acknowledged, especially their role in mediating …
Human blood CD1c+ dendritic cells encompass CD5high and CD5low subsets that differ significantly in phenotype, gene expression, and functions
X Yin, H Yu, X Jin, J Li, H Guo, Q Shi, Z Yin… - The Journal of …, 2017 - journals.aai.org
There are three major dendritic cell (DC) subsets in both humans and mice, that is,
plasmacytoid DCs and two types of conventional DCs (cDCs), cDC1s and cDC2s. cDC2s …
plasmacytoid DCs and two types of conventional DCs (cDCs), cDC1s and cDC2s. cDC2s …
Apoptotic cells induced signaling for immune homeostasis in macrophages and dendritic cells
U Trahtemberg, D Mevorach - Frontiers in immunology, 2017 - frontiersin.org
Inefficient and abnormal clearance of apoptotic cells (efferocytosis) contributes to systemic
autoimmune disease in humans and mice, and inefficient chromosomal DNA degradation by …
autoimmune disease in humans and mice, and inefficient chromosomal DNA degradation by …