Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons
C Yapo, AG Nair, L Clement, LR Castro… - The Journal of …, 2017 - Wiley Online Library
Key points Brief dopamine events are critical actors of reward‐mediated learning in the
striatum; the intracellular cAMP–protein kinase A (PKA) response of striatal medium spiny …
striatum; the intracellular cAMP–protein kinase A (PKA) response of striatal medium spiny …
Interrogating cyclic AMP signaling using optical approaches
Optical reporters for cAMP represent a fundamental advancement in our ability to investigate
the dynamics of cAMP signaling. These fluorescent sensors can measure changes in cAMP …
the dynamics of cAMP signaling. These fluorescent sensors can measure changes in cAMP …
[PDF][PDF] Liberated PKA catalytic subunits associate with the membrane via myristoylation to preferentially phosphorylate membrane substrates
Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization
of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA …
of PKA is controlled by A-kinase anchoring proteins (AKAPs). However, the dynamics of PKA …
AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons
K Gorshkov, S Mehta, S Ramamurthy… - Nature chemical …, 2017 - nature.com
Cyclic AMP (cAMP) and protein kinase A (PKA), classical examples of spatially
compartmentalized signaling molecules, are critical axon determinants that regulate …
compartmentalized signaling molecules, are critical axon determinants that regulate …
Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast
Due to recent military conflicts and terrorist attacks, blast-induced traumatic brain injury
(bTBI) presents a health concern for military and civilian personnel alike. Although …
(bTBI) presents a health concern for military and civilian personnel alike. Although …
Dendritic diameter influences the rate and magnitude of hippocampal cAMP and PKA transients during β-adrenergic receptor activation
In the hippocampus, cyclic-adenosine monophosphate (cAMP) and cAMP-dependent
protein kinase (PKA) form a critical signaling cascade required for long-lasting synaptic …
protein kinase (PKA) form a critical signaling cascade required for long-lasting synaptic …
Identification of potential type 4 cAMP phosphodiesterase inhibitors via 3D pharmacophore modeling, virtual screening, DFT and structural bioisostere design
Cyclic nucleotide phosphodiesterase Type 4 specifically metabolizes Cyclic Adenosine
Monophosphate and has widespread distribution across the human body. The aim of this …
Monophosphate and has widespread distribution across the human body. The aim of this …
Receptor-cyclic nucleotide microdomains in the heart
NI Bork, VO Nikolaev - Microdomains in the Cardiovascular System, 2017 - Springer
Abstract Cyclic nucleotides 3′, 5′-cyclic adenosine (cAMP) and 3′, 5′-cyclic guanosine
monophosphates (cGMP) are important second messengers which regulate cardiac function …
monophosphates (cGMP) are important second messengers which regulate cardiac function …
Guanine-nucleotide exchange modulator, GIV/Girdin, serves as a tunable valve for growth factor-stimulated cyclic AMP signals
M Getz, L Swanson, D Sahoo, P Ghosh, P Rangamani - bioRxiv, 2017 - biorxiv.org
Cellular levels of the versatile second messenger, cyclic-(c) AMP are regulated by the
antagonistic actions of the canonical G protein→ adenylyl cyclase pathway that is initiated …
antagonistic actions of the canonical G protein→ adenylyl cyclase pathway that is initiated …
Illuminating cyclic nucleotides: sensors for cAMP and cGMP and their application in live cell imaging
S Sharma, SS Visweswariah - Journal of the Indian Institute of Science, 2017 - Springer
Cyclic nucleotide monophosphates (cNMPs) act as second messengers in eukaryotic and
prokaryotic signaling pathways. Even though cNMPs regulate a wide variety of processes …
prokaryotic signaling pathways. Even though cNMPs regulate a wide variety of processes …