Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an
emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier …

Nuclear factor-κB (NF-κB) is a transcription factor regulating a wide array of genes mediating
numerous cellular processes such as proliferation, differentiation, motility and survival, to …

Acute myeloid leukemia (AML) is a heterogeneous malignancy. Despite the advances in
past decades, the clinical outcomes of AML patients remain poor. Leukemia stem cells …

P2X7 receptor is an ion channel activated by extracellular adenosine trisphosphate (eATP)
that attracted increasing attention for its role in immune reactions, neurobiology and …

Obesity is a growing problem in modern society and medicine. It closely associates with
metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and …

Microcystin-leucine arginine (MC-LR) causes testicular inflammation and hinders
spermatogenesis. However, the molecular mechanisms underlying the immune responses …

Abstract Objective MiR-486 and miR-146a are cardiomyocyte-enriched microRNAs that
control cell survival and self-regulation of inflammation. These microRNAs are released into …

Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are
chronic inflammatory rheumatic diseases that affect joints, causing debilitating pain and …

Background We previously discovered that tetracyclines increase the expression of lipid
phosphate phosphatases at the surface of cells. These enzymes degrade circulating …

Early social isolation (SI) produces a variety of emotional, behavioral and cognitive
abnormalities. Conversely, environmental enrichment (EE), a complicated social and …