Extent of resection in glioma–a review of the cutting edge

RS D'Amico, ZK Englander, P Canoll, JN Bruce - World neurosurgery, 2017 - Elsevier
Modern glioma surgery has evolved from the principal belief that safe, maximal tumor
resection improves symptom management, quality of life, progression-free survival, and …

Diffuse low-grade glioma: a review on the new molecular classification, natural history and current management strategies

PD Delgado-López, EM Corrales-García… - Clinical and …, 2017 - Springer
The management of diffuse supratentorial WHO grade II glioma remains a challenge
because of the infiltrative nature of the tumor, which precludes curative therapy after total or …

Mutant IDH1 and seizures in patients with glioma

H Chen, J Judkins, C Thomas, M Wu, L Khoury… - Neurology, 2017 - AAN Enterprises
Objective: Because the d-2-hydroxyglutarate (D2HG) product of mutant isocitrate
dehydrogenase 1 (IDH1mut) is released by tumor cells into the microenvironment and is …

Seizure control as a new metric in assessing efficacy of tumor treatment in low-grade glioma trials

EK Avila, M Chamberlain, D Schiff… - Neuro …, 2017 - academic.oup.com
Patients with low-grade glioma frequently have brain tumor–related epilepsy, which is more
common than in patients with high-grade glioma. Treatment for tumor-associated epilepsy …

Critical care management of cerebral edema in brain tumors

Y Esquenazi, VP Lo, K Lee - Journal of intensive care …, 2017 - journals.sagepub.com
Cerebral edema associated with brain tumors is extremely common and can occur in both
primary and metastatic tumors. The edema surrounding brain tumors results from leakage of …

Supratotal resection of diffuse gliomas–an overview of its multifaceted implications

YN Yordanova, H Duffau - Neurochirurgie, 2017 - Elsevier
Successful management of diffuse low-grade and high-grade gliomas in adults is a
challenge for neuro-oncologists. Indeed, due to their highly infiltrative feature, these …

Seizure response to perampanel in drug-resistant epilepsy with gliomas: early observations

C Vecht, A Duran-Peña, C Houillier, T Durand… - Journal of neuro …, 2017 - Springer
Drug-resistant epilepsy (DRE) occurs commonly in gliomas, possibly due to a shared
mechanism of AMPA-activation involving both seizure activity and tumor growth. We tested …

Surgery guided with intraoperative electrocorticography in patients with low-grade glioma and refractory seizures

PS Yao, SF Zheng, F Wang, DZ Kang, YX Lin - Journal of neurosurgery, 2017 - thejns.org
OBJECTIVE Using intraoperative electrocorticography (ECoG) to identify epileptogenic
areas and improve postoperative seizure control in patients with low-grade gliomas (LGGs) …

Seizures and anticonvulsants in brain tumours: frequency, mechanisms and anti-epileptic management

C Vecht, L Royer-Perron, C Houillier… - Current …, 2017 - ingentaconnect.com
In cancer, epilepsy can be the manifestation of a primary brain tumour, metastatic disease,
vascular or surgical complications, opportunistic infection or secondary to anti-tumour …

Clinical outcomes from maximum-safe resection of primary and metastatic brain tumors using awake craniotomy

A Groshev, D Padalia, S Patel, R Garcia-Getting… - Clinical neurology and …, 2017 - Elsevier
Objective To retrospectively analyze outcomes in patients undergoing awake craniotomies
for tumor resection at our institution in terms of extent of resection, functional preservation …