Background: Caffeic acid (CA) and related phenylpropanoic acids are ubiquitous natural
products of the shikimic acid pathway origin. Due to the presence of diorthohydroxyl …

The present chapter will review the role of σ 1 receptor in learning and memory and
neuroprotection, against Alzheimer's type dementia. σ 1 Receptor agonists have been tested …

Pursuing the strategy of developing potent AChE inhibitors, we attempted to carry out the N
1-substitution of 2, 3-dihydroquinazolin-4 (1H)-one core. A set of 32 N-alkylated/benzylated …

Alzheimer's disease has a complex multifactorial nature; therefore, a promising approach for
the development of efficient therapeutic agents is the concept of multitarget drugs, which …

A series of novel benzo [d] oxazole derivatives (6a–n) have been synthesized and
biologically evaluated as potential inhibitors of acetylcholinesterases (AC hE) and …

Biperiden is a drug used in Parkinson disease treatment and it serves also as an
antiseizures compound in organophosphates poisoning. It acts as antagonist of muscarinic …

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, which affected 35
million people in the world. The most practiced approach to improve the life expectancy of …

Abstract α-Isocubebenol (ICO) isolated from Schisandra chinensis fruit was recently shown
to exert neuroprotective properties with significant anti-neuroinflammatory effects. Here, we …

An increase activity of butyrylcholinesterase is believed to contribute to Alzheimer's disease.
Bambuterol is a known potent inhibitor of butyrylcholinesterase, but it has undesired cardiac …

The present study investigated the possible effect of BMMS in protecting against memory
impairment in an Alzheimer's disease model induced by scopolamine in mice. Another …