Background: Neovascularization, also known as angiogenesis, is the process of capillary
sprouting from pre-existing blood vessels. This physiological process is a hallmark event in …

Vascular endothelial growth factor receptor (VEGFR) tyrosine kinases are key regulators of
vascular development in vertebrates. Their activation is regulated through a family of …

Corticotrophin‐releasing hormone (CRH) has been demonstrated to participate in various
diseases. Our previous study showed that its receptor CRHR1 mediated the development of …

The ability to culture complex organs is currently an important goal in biomedical research. It
is possible to grow organoids (3D organ-like structures) in vitro; however, a major limitation …

Elevated plasma concentrations of soluble VEGFA isoforms are associated with poor
prognosis in parallel with improved response to treatment with the anti-VEGFA antibody …

The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …

Abnormal vasculature proliferation is one of the so-called hallmarks of cancer. Angiogenesis
inhibitor therapies are one of the major breakthroughs in cancer treatment in the last two …

We built a whole‐body computational model to study the role of the poorly understood
vascular endothelial growth factor (VEGF) 165b splice isoform in peripheral artery disease …

Peroxisome proliferator-activated receptor (PPAR) γ has been reported to be implicated in
placentation in mice. Previous studies have demonstrated that PPARγ is also expressed in …

Vascular endothelial growth factor A is a major mediator of angiogenesis, a critically
important process in vertebrate growth and development as well as pregnancy. Here we …