The focus on drug delivery for the pediatric population has been steadily increasing in the
last decades. In terms of developing in vitro models simulating characteristics of the targeted …

This study aimed to transform weakly acidic poorly water-soluble drugs (PWSD) into ionic
liquids (ILs) to promote solubility in, and the utility of, lipid-based formulations. Ionic liquids …

The simultaneous processes of lipid digestion and absorption together determine the oral
bioavailability of drugs incorporated into lipid based drug delivery systems (LBDDS). A …

Simulated gastrointestinal tract (GIT) models are commonly used to establish the major
factors influencing lipid digestion. In this study, two widely used static in vitro digestion …

Gastrointestinal fluid is a complex milieu and it is recognised that gut drug solubility is
different to that observed in simple aqueous buffers. Simulated gastrointestinal media have …

Aim: In this study, self-emulsifying drug delivery system (SEDDS) for oral delivery of opioid
peptide dalargin were developed and characterized in vitro. Methods: Dalargin lipophilicity …

In this study, we use molecular dynamics (MD) and experimental techniques (nephelometry
and dynamic light scattering) to investigate the influence of cholesterol content and pH on …

This study investigates the effect of monoacyl phospholipid incorporation on the in vitro and
in vivo performance of self-emulsifying drug delivery systems (SEDDS). Monoacyl …

The current studies sought to explore the impact of drug supersaturation and precipitation
during the dispersion and digestion of lipid-based formulations (LBFs), on in vivo absorption …

Objective The aim of the present study was to study the oral performance of furosemide in
neonates and young infants using a newly developed in vitro model simulating digestion …