Autophagy is a highly conserved protein degradation pathway from yeasts to humans that is
essential for removing protein aggregates and misfolded proteins in healthy cells. Recently …

Periodontitis is a highly prevalent infectious disease, characterized by destruction of the
periodontium, and is the main cause of tooth loss. Periodontitis is initiated by periodontal …

Rheumatoid arthritis (RA) is a complex and not fully understood autoimmune disease
associated with multijoint damage. The main effector cells, the synovial fibroblasts, are …

The hyperplastic growth of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) and
inflammatory response are pathological hallmarks of RA. It has been reported that …

Background and objective: Mounting studies have illustrated an important role of autophagy
in various diseases, but few studies have reported its contribution to rheumatoid arthritis …

Background Endoplasmic reticulum (ER) stress has proinflammatory properties, and
transgenic animal studies of rheumatoid arthritis (RA) indicate its relevance in the process of …

Autophagy is a tightly regulated mechanism that allows cells to renew themselves through
the lysosomal degradation of proteins, which are misfolded or produced in excess, and of …

Autophagy is involved in both innate and adaptive immune regulation. We propose that
autophagy regulates activation of TLR3 in macrophages and is thereby essential for …

The aim of this study was to investigate the effects of resveratrol (Res) on hydrogen peroxide
(H2O2)-treated fibroblast-like synoviocytes (FLSs) in vitro. We studied the phosphoinositide …

Wheat germ agglutinin (WGA) is a lectin that specifically binds cell surface glycoproteins and
disrupts nuclear pore complex function through its interaction with POM121. Our data …