Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …

Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

The canonical notion that type 1 diabetes (T1D) results following a complete destruction of β
cells has recently been questioned as small amounts of C-peptide are detectable in patients …

Abstract Type 1 diabetes (T1D) is a metabolic disease of unknown aetiology that results from
the autoimmune destruction of the β-cells. Clinical onset with classic hyperglycaemic …

Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of pancreatic β-cells
after an asymptomatic period over years. Insulitis activates antigen presenting cells, which …

Objectives Imaging studies are expected to produce reliable information regarding the size
and fat content of the pancreas. However, the available studies have produced inconclusive …

Context The cellular basis of persistent β-cell function in type 1 diabetes (T1D) remains
enigmatic. No extensive quantitative β-cell studies of T1D pancreata have been performed …

Abstract Purpose of Review Type 1 diabetes mellitus (T1DM) is an autoimmune disease that
results from the destruction of insulin-producing pancreatic β cells in the islets of …

Background Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the
rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to …