The changing landscape of clinical trial and approval processes in China

Q Zhou, XY Chen, ZM Yang, YL Wu - Nature Reviews Clinical …, 2017 - nature.com
In the past decade, the standards of clinical trials in China have moved closer to
international standards, thus encouraging the development of innovative drugs. However, a …

Comparison of prevalence and types of mutations in lung cancers among black and white populations

JD Campbell, C Lathan, L Sholl, M Ducar… - JAMA …, 2017 - jamanetwork.com
Importance Lung cancer is the leading cause of cancer death in the United States in all
ethnic and racial groups. The overall death rate from lung cancer is higher in black patients …

[HTML][HTML] Somatic mutations and ancestry markers in hispanic lung cancer patients

NT Gimbrone, B Sarcar, ER Gordian, JI Rivera… - Journal of Thoracic …, 2017 - Elsevier
Introduction To address the lack of genomic data from Hispanic/Latino (H/L) patients with
lung cancer, the Latino Lung Cancer Registry was established to collect patient data and …

Prevalence of EGFR mutations in lung cancer in Uruguayan population

N Berois, D Touya, L Ubillos, B Bertoni… - Journal of Cancer …, 2017 - Wiley Online Library
Background. Incorporation of molecular analysis of the epidermal growth factor receptor
(EGFR) gene into routine clinical practice represents a milestone for personalized therapy of …

[HTML][HTML] Racial disparity in metabolic regulation of cancer

KS Attri, D Murthy, PK Singh - Frontiers in bioscience (Landmark …, 2017 - ncbi.nlm.nih.gov
Genetic mutations and metabolic reprogramming are two key hallmarks of cancer, required
for proliferation, invasion, and metastasis of the disease. While genetic mutations, whether …

Lung adenocarcinoma survival in EGFR-Mutated African-Caribbean patients: a multicenter study in the French West Indies

N Leduc, V Atallah, M Agossou, V Vinh-Hung, M Orre… - Targeted …, 2017 - Springer
Background Lung cancer is the leading cause of cancer-related death worldwide. Shorter
survival has been repeatedly reported for patients of African ancestry. Multivariate analysis …

[HTML][HTML] Impact of country of birth on genetic testing of metastatic lung adenocarcinomas in France: African women exhibit a mutational spectrum more similar to …

R Saffroy, JF Morère, N Bosselut, PF Innominato… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Limited data are available on the prevalence of oncogenic driver mutations in
Caucasian populations, and especially in Europeans. Aim To evaluate the targetable …

[HTML][HTML] Feasibility of molecular testing in a multicenter study with geographical variation in India: Epidermal growth factor receptor mutation as a model molecular test

K Prabhash, A Rauthan, S Rajappa… - Asian Journal of …, 2017 - thieme-connect.com
Context: Trends in epidermal growth factor receptor (EGFR) mutation based on ethnicity
assist the initial selection of targeted therapy regimen. Reported incidence of EGFR mutation …