Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious
disease which results in approximately 10 million incident cases and 1.4 million deaths …

Faithful replication and maintenance of the genome are essential to the ability of any
organism to survive and propagate. For an obligate pathogen such as Mycobacterium …

Mycobacterium tuberculosis has succeeded as a human pathogen for tens of thousands of
years thanks to its ability to resist and adapt to the adverse conditions it encounters upon …

Reversible protein phosphorylation is the most common type of epigenetic posttranslational
modification in living cells used as a major regulation mechanism of biological processes …

Abstract imuABC (imuAB dnaE2) genes are responsible for SOS-mutagenesis in
Caulobacter crescentus and other bacterial species devoid of umuDC. In this work, we have …

Translesion DNA synthesis (TLS), facilitated by low-fidelity polymerases, is an important
DNA damage tolerance mechanism. Here, we investigated the role and biological function …

DNA replication is fundamental for life, yet a detailed understanding of bacterial DNA
replication is limited outside the organisms Escherichia coli and Bacillus subtilis. Many …

Mycobacterium tuberculosis is genetically isolated, with no evidence for horizontal gene
transfer or the acquisition of episomal genetic information in the modern evolution of strains …

Mutator strains were identified by screening random Tn5 insertion clones of Caulobacter
crescentus. We identified clones with robust increases in mutation rates with Tn5 insertions …

Background: Mycobacterium tuberculosis (M. tuberculosis), the causative agent of
tuberculosis, is a leading infectious disease organism, causing millions of deaths each year …