A cancer cell-centric view has long dominated the field of cancer biology. Research efforts
have focussed on aberrant cancer cell signalling pathways and on changes to cancer cell …

The mouse mammary gland is widely used as a model for human breast cancer and has
greatly added to our understanding of the molecular mechanisms involved in breast cancer …

High doses of estrogenic pharmaceuticals were once prescribed to women to halt lactation.
Yet, the effects of low-level xenoestrogens on lactation remain poorly studied. We …

Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) have
been shown to function downstream of several peptide hormones and cytokines that are …

The Hedgehog signaling network regulates organogenesis, cell fate, proliferation, survival,
and stem cell self-renewal in many mammalian tissues. Aberrant activation of the Hedgehog …

The aim of this study was to investigate heterogeneity in tissue morphology, milk protein and
immune-related gene expression, and apoptosis of epithelial cells in the lactating and …

To examine tight junction protein abundance and apoptosis of epithelial cells at the onset of
involution in rodent mammary glands, milk accumulation and mammary engorgement were …

Abstract α-lactalbumin is a protein of dual function found in milk of most mammals. α-
lactalbumin binds β-1, 4-galactosyltransferase to form the regulatory subunit for lactose …

In rodents, post‐lactational involution of mammary glands is characterized by the loss of
mammary epithelial cells via apoptosis, which is associated with a decline in the expression …

Mammary gland is a unique organ with its function of milk synthesis, secretion, and
involution to prepare the gland for subsequent lactation. The mammary epithelial cells …