How introns enhance gene expression
O Shaul - The international journal of biochemistry & cell biology, 2017 - Elsevier
In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …
gene expression without functioning as a binding site for transcription factors. This …
The exon junction complex: a lifelong guardian of mRNA fate
During messenger RNA (mRNA) biogenesis and processing in the nucleus, many proteins
are imprinted on mRNAs assembling them into messenger ribonucleoproteins (mRNPs) …
are imprinted on mRNAs assembling them into messenger ribonucleoproteins (mRNPs) …
The role of alternative splicing coupled to nonsense-mediated mRNA decay in human disease
PJ da Costa, J Menezes, L Romão - … Journal of Biochemistry & Cell Biology, 2017 - Elsevier
Alternative pre-mRNA splicing (AS) affects gene expression as it generates proteome
diversity. Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that …
diversity. Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that …
Modulation of nonsense mediated decay by rapamycin
RT Martinez-Nunez, A Wallace, D Coyne… - Nucleic acids …, 2017 - academic.oup.com
Rapamycin is a naturally occurring macrolide whose target is at the core of nutrient and
stress regulation in a wide range of species. Despite well-established roles as an inhibitor of …
stress regulation in a wide range of species. Despite well-established roles as an inhibitor of …
Transcript-specific characteristics determine the contribution of endo-and exonucleolytic decay pathways during the degradation of nonsense-mediated decay …
Nonsense-mediated mRNA decay (NMD) controls gene expression by eliminating mRNAs
with premature or aberrant translation termination. Degradation of NMD substrates is …
with premature or aberrant translation termination. Degradation of NMD substrates is …
Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay
Spliceostatin A, meayamycin, and pladienolide B are small molecules that target the SF3b
subunit of the spliceosomal U2 small nuclear ribonucleoprotein (snRNP). These compounds …
subunit of the spliceosomal U2 small nuclear ribonucleoprotein (snRNP). These compounds …
Examining the intersection between splicing, nuclear export and small RNA pathways
A Nabih, JA Sobotka, MZ Wu, CJ Wedeles… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abstract Background Nuclear Argonaute/small RNA pathways in a variety of eukaryotic
species are generally known to regulate gene expression via chromatin modulation and …
species are generally known to regulate gene expression via chromatin modulation and …
The Discovery of EJC Independent Roles for EIF4A3 in Mitosis, Microtubules, and Neural Crest Development
EE Miller - 2017 - search.proquest.com
Duke University Dissertation Template Page 1 i The Discovery of EJC Independent Roles
for EIF4A3 in Mitosis, Microtubules, and Neural Crest Development by Emily Elizabeth …
for EIF4A3 in Mitosis, Microtubules, and Neural Crest Development by Emily Elizabeth …
Twist of messenger Fate: novel mechanisms for TDP43 in modulating mRNA decay and alternative polyadenylation
V Potrich - 2017 - eprints-phd.biblio.unitn.it
TDP43 is an ubiquitously expressed RNA-binding protein implicated in several aspects of
RNA metabolism. It can shuttle between the nucleus and the cytoplasm; however, when it is …
RNA metabolism. It can shuttle between the nucleus and the cytoplasm; however, when it is …
EIF4A3 associated splicing and nonsense mediated decay defined by a systems analysis with novel small molecule inhibitors
Chemical biology approaches to the global functions of splicing reactions are gaining
momentum, with an increasing repertoire of small molecule probes becoming available …
momentum, with an increasing repertoire of small molecule probes becoming available …