Control of gene expression through the nonsense-mediated RNA decay pathway
A Nickless, JM Bailis, Z You - Cell & bioscience, 2017 - Springer
Nonsense-mediated RNA decay (NMD) was originally discovered as a cellular surveillance
pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical …
pathway that safeguards the quality of mRNA transcripts in eukaryotic cells. In its canonical …
Stress and the nonsense-mediated RNA decay pathway
AE Goetz, M Wilkinson - Cellular and Molecular Life Sciences, 2017 - Springer
Cells respond to internal and external cellular stressors by activating stress-response
pathways that re-establish homeostasis. If homeostasis is not achieved in a timely manner …
pathways that re-establish homeostasis. If homeostasis is not achieved in a timely manner …
Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6-and SMG7-mediated degradation pathways
M Colombo, ED Karousis, J Bourquin, R Bruggmann… - Rna, 2017 - rnajournal.cshlp.org
Besides degrading aberrant mRNAs that harbor a premature translation termination codon
(PTC), nonsense-mediated mRNA decay (NMD) also targets many seemingly “normal” …
(PTC), nonsense-mediated mRNA decay (NMD) also targets many seemingly “normal” …
The role of alternative splicing coupled to nonsense-mediated mRNA decay in human disease
PJ da Costa, J Menezes, L Romão - … Journal of Biochemistry & Cell Biology, 2017 - Elsevier
Alternative pre-mRNA splicing (AS) affects gene expression as it generates proteome
diversity. Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that …
diversity. Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that …
A GC-rich sequence feature in the 3′ UTR directs UPF1-dependent mRNA decay in mammalian cells
Up-frameshift protein 1 (UPF1) is an ATP-dependent RNA helicase that has essential roles
in RNA surveillance and in post-transcriptional gene regulation by promoting the …
in RNA surveillance and in post-transcriptional gene regulation by promoting the …
[HTML][HTML] Nonsense-mediated mRNA decay at the crossroads of many cellular pathways
F Lejeune - BMB reports, 2017 - ncbi.nlm.nih.gov
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast
decay of mRNAs harboring a premature termination codon (PTC). As a quality control …
decay of mRNAs harboring a premature termination codon (PTC). As a quality control …
Plasmid transfection influences the readout of nonsense-mediated mRNA decay reporter assays in human cells
JV Gerbracht, V Boehm, NH Gehring - Scientific reports, 2017 - nature.com
Messenger RNA (mRNA) turnover is a crucial and highly regulated step of gene expression
in mammalian cells. This includes mRNA surveillance pathways such as nonsense …
in mammalian cells. This includes mRNA surveillance pathways such as nonsense …
Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins
J Jia, E Werkmeister… - Journal of Cell …, 2017 - journals.biologists.com
Nonsense-mutation-containing messenger ribonucleoprotein particles (mRNPs) transit
through cytoplasmic foci called P-bodies before undergoing nonsense-mediated mRNA …
through cytoplasmic foci called P-bodies before undergoing nonsense-mediated mRNA …
[HTML][HTML] Multifaceted regulation of gene expression by the apoptosis-and splicing-associated protein complex and its components
B Deka, KK Singh - International journal of biological sciences, 2017 - ncbi.nlm.nih.gov
The differential deposition of RNA-binding proteins (RBPs) on pre-mRNA mediates the
processes of gene expression. One of the complexes containing RBPs that play a crucial …
processes of gene expression. One of the complexes containing RBPs that play a crucial …