Medications development for the treatment of alcohol use disorder: insights into the predictive value of animal and human laboratory models

MM Yardley, LA Ray - Addiction biology, 2017 - Wiley Online Library
Abstract Development of effective treatments for alcohol use disorder (AUD) represents an
important public health goal. This review provides a summary of completed preclinical and …

Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children

EM Teshome, PEA Andang'o, V Osoti, SR Terwel… - BMC medicine, 2017 - Springer
Background We aimed to show the non-inferiority of home fortification with a daily dose of 3
mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) …

A studentized permutation test for three‐arm trials in the 'gold standard'design

T Mütze, F Konietschke, A Munk… - Statistics in Medicine, 2017 - Wiley Online Library
The 'gold standard'design for three‐arm trials refers to trials with an active control and a
placebo control in addition to the experimental treatment group. This trial design is …

The ethics of clinical trials research in severe mood disorders

AC Nugent, FG Miller, ID Henter, CA Zarate Jr - Bioethics, 2017 - Wiley Online Library
Mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are
highly prevalent, frequently disabling, and sometimes deadly. Additional research and more …

[HTML][HTML] Comparison of home fortification with two iron formulations among Kenyan children: Rationale and design of a placebo-controlled non-inferiority trial

EM Teshome, W Otieno, SR Terwel, V Osoti… - Contemporary clinical …, 2017 - Elsevier
Introduction Home fortification powders containing iron and other micronutrients have been
recommended by World Health Organisation to prevent iron deficiency anaemia in areas of …

A pilot randomised controlled trial comparing antipsychotic medication, to cognitive behavioural therapy to a combination of both in people with psychosis: rationale …

H Law, L Carter, R Sellers, R Emsley, R Byrne… - Psychosis, 2017 - Taylor & Francis
Aims: Ongoing NICE guidance recommends research on the clinical and cost effectiveness
of psychological treatment alone, compared to antipsychotic medication and compared to …

Drug versus placebo randomized controlled trials in neonates: A review of ClinicalTrials. gov registry

E Desselas, C Pansieri, S Leroux, M Bonati… - Plos one, 2017 - journals.plos.org
Background Despite specific initiatives and identified needs, most neonatal drugs are still
used off-label, with variable dosage administrations and schedules. In high risk preterm and …

[图书][B] Informed choice of medical services: is the law just?

M Milburn - 2017 - taylorfrancis.com
This title was first published in 2001. This work is a uniquely multi-disciplinary contribution to
the existing bioethical literature on the topic of informed choice of medical services. It is also …

A placebo alkalmazásának etikai vonatkozásai

V Bodnár, G Bárdos - Magyar Pszichológiai Szemle, 2017 - akjournals.com
Jelen tanulmány a placebo terápiás és klinikai kutatásokban történő felhasználásának etikai
kérdéseit veszi sorra, külön hangsúlyt helyezve a megtévesztés, az egészségügyi hátrány, a …

Regulating research for the decisionally impaired: implications for mental health professionals

MB Kapp - Human Experimentation and Research, 2017 - taylorfrancis.com
Mental health professionals, in fulfilling their different roles, often become involved with
research protocols involving decisionally impaired current or prospective human subjects …