HSP90: a promising broad-spectrum antiviral drug target
Y Wang, F Jin, R Wang, F Li, Y Wu, K Kitazato… - Archives of …, 2017 - Springer
The emergence of antiviral drug-resistant mutants is the most important issue in current
antiviral therapy. As obligate parasites, viruses require host factors for efficient replication …
antiviral therapy. As obligate parasites, viruses require host factors for efficient replication …
[HTML][HTML] Resveratrol induces cell cycle arrest and apoptosis with docetaxel in prostate cancer cells via a p53/p21WAF1/CIP1 and p27KIP1 pathway
Resveratrol (RES) is the most effective natural products used for the treatment of a variety of
cancers. In this study, we tested the effect of RES in enhancing the efficacy of docetaxel …
cancers. In this study, we tested the effect of RES in enhancing the efficacy of docetaxel …
[HTML][HTML] A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive …
K Jhaveri, R Wang, E Teplinsky, S Chandarlapaty… - Breast Cancer …, 2017 - Springer
Background Targeted therapies in HER2-positive metastatic breast cancer significantly
improve outcomes but efficacy is limited by therapeutic resistance. HER2 is an acutely …
improve outcomes but efficacy is limited by therapeutic resistance. HER2 is an acutely …
Sigma1 targeting to suppress aberrant androgen receptor signaling in prostate cancer
JD Thomas, CG Longen, HM Oyer, N Chen, CM Maher… - Cancer research, 2017 - AACR
Suppression of androgen receptor (AR) activity in prostate cancer by androgen depletion or
direct AR antagonist treatment, although initially effective, leads to incurable castration …
direct AR antagonist treatment, although initially effective, leads to incurable castration …
Molecular chaperone HSP90 is necessary to prevent cellular senescence via lysosomal degradation of p14ARF
The tumor suppressor function of p14ARF is regulated at a posttranslational level via
mechanisms yet to be fully understood. Here, we report the identification of an …
mechanisms yet to be fully understood. Here, we report the identification of an …
Injectable Nanogels in Drug Delivery
M Ansuja Pulickal, S Uthaman, CS Cho, IK Park - 2017 - books.rsc.org
Gels are dispersions of a discontinuous liquid phase molecule in a continuous solid phase,
or, they are dilute cross-linked systems with three dimensional networks within an extending …
or, they are dilute cross-linked systems with three dimensional networks within an extending …
Methods and compositions related to annexin 1-binding compounds
M Fukuda, K Sugihara, N Kanayama - US Patent 9,610,359, 2017 - Google Patents
US9610359B2 - Methods and compositions related to annexin 1-binding compounds -
Google Patents US9610359B2 - Methods and compositions related to annexin 1-binding …
Google Patents US9610359B2 - Methods and compositions related to annexin 1-binding …
New Mechanism Based Approaches For Treating Prostate Cancer
R Rosati - 2017 - digitalcommons.wayne.edu
Prostate cancer (PC) is generally dependent on the androgen signaling axis for tumor
growth. PC is managed by androgen deprivation therapy (ADT). The tumors then frequently …
growth. PC is managed by androgen deprivation therapy (ADT). The tumors then frequently …
Methods and Compositions Related To Annexin 1-Binding Compounds
M Fukuda, K Sugihara, N Kanayama - US Patent App. 15/478,699, 2017 - Google Patents
US20170326245A1 - Methods and Compositions Related To Annexin 1-Binding
Compounds - Google Patents US20170326245A1 - Methods and Compositions Related To …
Compounds - Google Patents US20170326245A1 - Methods and Compositions Related To …