ABSTRACT A variant within the gene locus encoding PTPN22 (protein tyrosine
phosphatase, non-receptor type 22) emerged as an important risk factor for auto …

Endometriosis is a benign gynecologic disorder, affecting up to 10% of women,
characterized by the presence of functional endometrial tissue at ectopic positions generally …

Objectives: Several rheumatoid arthritis (RA) susceptibility loci have also been found to be
associated with psoriatic arthritis (PsA), demonstrating that there is a degree of genetic …

Abstract Interferon regulatory factor 5 (IRF5) regulates type I interferon (IFN)-responsive
genes, and has been one of the most consistently associated genes with systemic lupus …

Previous studies have explored the relationship of PTPN22 and TLR9 polymorphisms with
systemic lupus erythematosus (SLE). In consideration of the population stratification …

Studies performed in the past years showed PTNP22 1858 C> T (rs2476601) polymorphism
as associated with systemic lupus erythematosus susceptibility, although conflicting findings …

Juvenile idiopathic arthritis (JIA) the most common chronic arthropathy of childhood is a
diverse group of chronic arthritis diseases. The protein tyrosine phosphatase N22 (PTPN22) …

Endocarditis and heart defects develop at ¾ of patients with systemic lupus erythematosus,
among which the defeat of the mitral valve was observed in all cases, aortic valve-at every …

Background: Systemic lupus erythematosus (SLE), a systemic autoimmune disease, occurs
due to disruption of immune homeostasis against self-antigens. The etiology of SLE is …