Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins
have been investigated by pharmaceutical companies as drug targets. The first clinical …

Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host
components that compose the tumor is termed the tumor microenvironment (TME). Host cells …

There is considerable interest in the physiology and pathology, as well as the cellular and
molecular biology, of bone marrow adipose tissue (BMAT). Because bone marrow adiposity …

Background The lysosomal cysteine protease cathepsin K is involved in bone remodeling
and is also expressed in the peritumoral stroma of carcinomas arising from different organs …

Membrane-compound exchange is vital for cell-to-cell communication, yet quantification of
this process is difficult. Here we present a method using flow cytometry in combination with …

Abstract Context Tumor-associated macrophages (TAMs) constitute a heterogenous
population and are highly represented in prostate cancer (PCa) primary tumor and …

Proteases are one of the most common enzyme families in the world. Proteases have been
used more effectively in recent years in fighting cancer. There are numerous reviews in the …

Le collagène de type II, qui confère au cartilage articulaire sa résistance à la tension, est
détruit dans l'arthrose. La cathepsine K est reconnue comme pouvant cliver le collagène de …