Underpinning the vision of precision medicine is the concept that causative mutations in a
patient's cancer drive its biology and, by extension, its clinical features and treatment …

The success of all-trans retinoic acid (ATRA) therapy for acute promyelocytic leukemia (APL)
provides a rationale for using retinoic acid (RA)-based therapy for other subtypes of acute …

We evaluated the impact of salvage regimens and allogeneic hematopoietic cell
transplantation (allo-HCT) in acute myeloid leukemia (AML) with induction failure. Between …

Despite intensive induction and consolidation therapy in newly diagnosed patients with
acute myeloid leukemia (AML), approximately half of the younger patients and about 80 …

We have previously identified a recurrent deletion at chromosomal band 3p14. 1-p13 in
patients with acute myeloid leukemia (AML). Among eight protein-coding genes, this …

When analyzing clinical trials with a stratified population, homogeneity of treatment effects is
a common assumption in survival analysis. However, in the context of recent developments …

全反式维甲酸对NPM1突变的白血病细胞系U937细胞的作用及其机制研究- PMC Back to Top
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Objective: To investigate the effect and mechanism of all-trans retinoic acid (ATRA) on
leukemic cell line U937 cells with NPM1 mutation. Methods: Human acute myeloid leukemia …

Diese Arbeit untersucht den Einfluss verschiedener Salvagetherapien und der allogenen
hämatopoetischen Stammzelltransplantation (allo-HCT) auf das Ansprechen und …

Differentiation therapies are a promising alternative to genotoxic-based chemotherapies in
the treatment of many cancers. In particular, All-trans-retinoic acid (ATRA) is successfully …