Abstract The 4D Nucleome Network aims to develop and apply approaches to map the
structure and dynamics of the human and mouse genomes in space and time with the goal …

Animal development depends on not only the linear genome sequence that embeds millions
of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that …

Chromosome conformation capture technologies have revealed important insights into
genome folding. Yet, how spatial genome architecture is related to gene expression and cell …

There is considerable evidence that chromosome structure plays important roles in gene
control, but we have limited understanding of the proteins that contribute to structural …

The human genome folds to create thousands of intervals, called" contact domains," that
exhibit enhanced contact frequency within themselves." Loop domains" form because of …

We describe Cleavage Under Targets and Release Using Nuclease (CUT&RUN), a
chromatin profiling strategy in which antibody-targeted controlled cleavage by micrococcal …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …

The spatial organization of the genome plays an important role in the regulation of gene
expression. However, the core structural features of animal genomes, such as topologically …

Many genetic variants that influence phenotypes of interest are located outside of protein-
coding genes, yet existing methods for identifying such variants have poor predictive power …

Recent studies indicate that even a homogeneous population of cells display heterogeneity
in gene expression and response to environmental stimuli. Although promoter structure …