Emerging infections have threatened humanity since times immemorial. The dramatic
anthropogenic, behavioral and social changes that have affected humanity and the …

Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently
into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene …

Understanding Viruses continues to set the standard for the fundamentals of virology. This
classic textbook combines molecular, clinical, and historical aspects of human viral diseases …

The entry of HIV-1 into target cells is mediated by the viral envelope glycoproteins (Env).
Binding to the CD4 receptor triggers a cascade of conformational changes in distant …

HIV-1 replication requires myriad interactions between cellular proteins and the viral
unspliced RNA. These interactions are important in archetypal RNA processes such as …

Transcription activator-like effector nuclease (TALEN) represents a valuable tool for genomic
engineering due to its single-nucleotide precision, high nuclease activity, and low …

Interactions between the gp120 and gp41 subunits of the human immunodeficiency virus
type 1 (HIV-1) envelope glycoprotein (Env) trimer maintain the metastable unliganded form …

Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the viral
envelope glycoproteins (Env), a trimer of three gp120 exterior glycoproteins, and three gp41 …

Pathogens have evolved unique mechanisms to breach the cell surface barrier and
manipulate the host immune response to establish a productive infection. Proteins exposed …

Global transcriptome studies can help pinpoint key cellular pathways exploited by viruses to
replicate and cause pathogenesis. Previous data showed that laboratory-adapted HIV-1 …