The increasing understanding of the role of nitric oxide (NO) in cancer biology has
generated significant progress in the use of NO donor-based therapy to fight cancer. These …

While commonly known for degradation of the extracellular matrix, matrix metalloproteinases
(MMPs) exhibit broad potential for use in targeting of bioactive and imaging agents in cancer …

Fluorouracil (5‐FU) is one of the most commonly used chemotherapeutic agents in colon
cancer treatment, but has a narrow therapeutic index limited by its toxicity. Melatonin exerts …

Accumulating evidence suggests the idea that chronic inflammation may play a critical role
in various malignancies including bladder cancer and long-term treatment with non-steroidal …

Cancer is a multifactorial disease including interactions of complex genetic and
environmental factors. Clinical efficacy of anticancer chemotherapies is hampered by …

We report for the first time the development of a two-photon excitable NO photoreleaser,
CNNO, for ratiometric imaging and tracking of NO release in live cells. CNNO exhibits the …

Background/Aims: The effects of zinc signaling on proliferation or apoptosis of leukemia
cells remain elusive. In the present study, we used N, N, N', N'-tetrakis-(2-pyridylmethyl) …

Nitric oxide synthase 2, inducible (Nos2) expression is necessary for the microbicidal activity
of macrophages. However, NOS2 over-activation causes multiple inflammatory disorders …

We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on
normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the …

Background In view of the fact that JS-K might regulate ubiquitin E3 ligase and that ubiquitin
E3 ligase plays an important role in the mechanism of CRPC formation, the goal was to …