Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

A highly protective malaria vaccine would greatly facilitate the prevention and elimination of
malaria and containment of drug-resistant parasites. A high level (more than 90%) of …

Background Analysis of the varied developmental pathways exploited by malarial parasites
as they pass through their differing life stages can be challenging [1–3], the parasites often …

Background A drug for causal (ie, pre-erythrocytic) prophylaxis of Plasmodium falciparum
malaria with prolonged activity would substantially advance malaria control. DSM265 is an …

Since the turn of the century, a remarkable expansion has been achieved in the range and
effectiveness of products and strategies available to prevent, treat, and control malaria …

Modern controlled human malaria infection (CHMI) clinical trials have almost entirely
focussed on Plasmodium falciparum, providing a highly informative means to investigate …

Malaria sporozoites must first undergo intrahepatic development before a pathogenic blood-
stage infection is established. The success of infection depends on host and parasite factors …

Introduction: Despite recent advances, malaria remains a major health threat both to
populations in endemic areas as well travelers, including military personnel, to these areas …

Background The sexual stages (gametocytes) of Plasmodium falciparum do not directly
contribute to the pathology of malaria but are essential for transmission of the parasite from …

Abstract Controlled Human Malaria Infection (CHMI) is the most practiced controlled human
infection model nowadays and there is an exponential increase in implementation of the …