Noncoding DNA regions have central roles in human biology, evolution, and disease.
ChromHMM helps to annotate the noncoding genome using epigenomic information across …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's
disease. Under pathological conditions, Tau dissociates from axonal microtubules and …

Many plants, including some of the commonly consumed herbs and spices in our daily food,
can be safely and effectively used to prevent and/or treat some health concerns. For …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …

Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …

There are currently no disease-modifying therapies for the treatment of tauopathies, a group
of progressive neurodegenerative disorders that are pathologically defined by the presence …

Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic
protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are …