The ability to rapidly adapt cellular bioenergetic capabilities to meet rapidly changing
environmental conditions is mandatory for normal cellular function and for cancer …

The bone marrow microenvironment (BMME) is a complex ecosystem that instructs and
protects hematopoietic stem cells (HSCs) and their malignant counterparts, the leukemia …

Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …

Background and Purpose—Recent studies suggest that extracellular mitochondria may be
involved in the pathophysiology of stroke. In this study, we assessed the functional …

Altered metabolism is a distinct feature of cancer cells. During transformation, the entire
metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to …

Tumors adapt to an unfavorable microenvironment by controlling the balance between cell
proliferation and cell motility, but the regulators of this process are largely unknown. Here …

The view that genes are constrained within somatic cells is challenged by in vitro evidence,
and more recently by in vivo studies which demonstrate that mitochondria with their …

There are approximately 1500 proteins that are needed for mitochondrial structure and
function, most of which are encoded in the nuclear genome (Calvo et al., 2006). Each …

Mitochondrial electron transport chain (ETC) targeting shows a great promise in cancer
therapy. It is particularly effective in tumors with high ETC activity where ETC-derived …

Предпосылки и цель исследования. Результаты последних исследований показывают,
что внеклеточные митохондрии могут участвовать в патофизиологии инсульта. В …