Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G Jin… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Viscoelastic hydrogels for 3D cell culture

O Chaudhuri - Biomaterials science, 2017 - pubs.rsc.org
In tissues, many cells are surrounded by and interact with a three-dimensional soft
extracellular matrix (ECM). Both the physical and biochemical properties of the ECM play a …

Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling

CM Madl, BL LeSavage, RE Dewi, CB Dinh… - Nature materials, 2017 - nature.com
Neural progenitor cell (NPC) culture within three-dimensional (3D) hydrogels is an attractive
strategy for expanding a therapeutically relevant number of stem cells. However, relatively …

Fabrication of injectable high strength hydrogel based on 4-arm star PEG for cartilage tissue engineering

J Wang, F Zhang, WP Tsang, C Wan, C Wu - Biomaterials, 2017 - Elsevier
Hydrogels prepared from poly (ethylene glycol)(PEG) are widely applied in tissue
engineering, especially those derived from a combination of functional multi-arm star PEG …

Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

HW Ooi, S Hafeez, CA Van Blitterswijk, L Moroni… - Materials …, 2017 - pubs.rsc.org
The past decade has seen a decided move from static and passive biomaterials to
biodegradable, dynamic, and stimuli responsive materials in the laboratory and the clinic …

3D hydrogel scaffold doped with 2D graphene materials for biosensors and bioelectronics

HS Song, OS Kwon, JH Kim, J Conde, N Artzi - Biosensors and …, 2017 - Elsevier
Hydrogels consisting of three-dimensional (3D) polymeric networks have found a wide
range of applications in biotechnology due to their large water capacity, high …

New advances in probing cell–extracellular matrix interactions

AP Liu, O Chaudhuri, SH Parekh - Integrative biology, 2017 - academic.oup.com
The extracellular matrix (ECM) provides structural and biochemical support to cells within
tissues. An emerging body of evidence has established that the ECM plays a key role in cell …

Toward next-generation bioinks: tuning material properties pre-and post-printing to optimize cell viability

AL Rutz, PL Lewis, RN Shah - Mrs Bulletin, 2017 - cambridge.org
Bioprinting, the three-dimensional (3D) printing of cell-laden inks, will be a truly
revolutionary technology for the biomaterials community. The number of bioink studies …

3D printing of biocomposites for osteochondral tissue engineering

C Vyas, G Poologasundarampillai, J Hoyland… - Biomedical …, 2017 - Elsevier
Abstract 3D printing in tissue engineering and regenerative medicine has vastly expanded
in recent years due to the ability to fabricate complex multimaterial biomimetic structures that …

Tyrosine-selective functionalization for bio-orthogonal cross-linking of engineered protein hydrogels

CM Madl, SC Heilshorn - Bioconjugate chemistry, 2017 - ACS Publications
Engineered protein hydrogels have shown promise as artificial extracellular matrix materials
for the 3D culture of stem cells due to the ability to decouple hydrogel biochemistry and …