Bipolar affective disorder is a common neuropsychiatric disorder. Although its
neurobiological underpinnings are incompletely understood, the dopamine hypothesis has …

Objectives Suicide and suicidal behaviour are increased in mood disorders, particularly
bipolar disorders. Observational studies and small randomized controlled trials (RCTs) …

Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more
years, and recent studies with more reliable designs and updated guidelines have …

Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge
for clinicians and women with mental health problems, owing to the uncertainties around …

Background Lithium is an effective mood stabilizer that is used principally for the
management of bipolar disorder (BD). Its administration is complex and often requires …

Lithium is a commonly prescribed treatment for bipolar affective disorder. However,
treatment is complicated by lithium's narrow therapeutic index and the influence of kidney …

Lithium has literally been everywhere forever, since it is one of the three elements created in
the Big Bang. Lithium concentration in rocks, soil, and fresh water is highly variable from …

Abstract Treatment resistance to the antidepressive pharmacotherapy represents one of the
most important clinical challenges in the pharmacological management of unipolar …

In their Comment in The Lancet Psychiatry, John B Saunders and colleagues1 aptly
described current debates regarding the consideration and classification of gambling and …

Background Concerns about potential adverse effects of long-term exposure to lithium as a
mood-stabilizing treatment notably include altered renal function. However, the incidence of …