Pathological overproduction: the bad side of adenosine

PA Borea, S Gessi, S Merighi… - British journal of …, 2017 - Wiley Online Library
Adenosine is an endogenous ubiquitous purine nucleoside, which is increased by hypoxia,
ischaemia and tissue damage and mediates a number of physiopathological effects by …

Pulmonary hypertension associated with idiopathic pulmonary fibrosis: current and future perspectives

SD Collum, J Amione-Guerra… - Canadian respiratory …, 2017 - Wiley Online Library
Pulmonary hypertension (PH) is commonly present in patients with chronic lung diseases
such as Chronic Obstructive Pulmonary Disease (COPD) or Idiopathic Pulmonary Fibrosis …

[HTML][HTML] HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis

K Philip, TW Mills, J Davies, NY Chen… - The FASEB …, 2017 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a deadly chronic lung disease. Extracellular
accumulation of adenosine and subsequent activation of the ADORA2B receptor play …

Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis

SD Collum, NY Chen, AM Hernandez… - British journal of …, 2017 - Wiley Online Library
Background and Purpose Group III pulmonary hypertension (PH) is a highly lethal and
widespread lung disorder that is a common complication in idiopathic pulmonary fibrosis …

Adenosine receptors as drug targets for treatment of pulmonary arterial hypertension

AKN Alencar, GC Montes, EJ Barreiro… - Frontiers in …, 2017 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a clinical condition characterized by pulmonary
arterial remodeling and vasoconstriction, which promote chronic vessel obstruction and …

Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades

F Wirsdörfer, V Jendrossek - Radiation oncology, 2017 - Springer
Radiation-induced pneumonitis and fibrosis represent severe and dose-limiting side effects
in the radiotherapy of thorax-associated neoplasms leading to decreased quality of life or-as …

The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease

KM Philip - 2017 - digitalcommons.library.tmc.edu
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects 5-8 million
individuals worldwide and 200,000 individuals in the United States alone. Although …

[引用][C] Pulmonary Hypertension due to Lung Diseases and/or Hypoxia: What Do We Actually Know?