Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance
HA Khan, MZ Ahmad, JA Khan, MI Arshad - Hepatobiliary & pancreatic …, 2017 - Elsevier
Background Liver inflammation or hepatitis is a result of pluripotent interactions of cell death
molecules, cytokines, chemokines and the resident immune cells collectively called as …
molecules, cytokines, chemokines and the resident immune cells collectively called as …
Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity
K Du, A Farhood, H Jaeschke - Archives of toxicology, 2017 - Springer
Acetaminophen (APAP) hepatotoxicity is characterized by an extensive mitochondrial
oxidant stress. However, its importance as a drug target has not been clarified. To …
oxidant stress. However, its importance as a drug target has not been clarified. To …
Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity
JP Simon, S Evan Prince - Journal of Applied Toxicology, 2017 - Wiley Online Library
The liver is an important organ of the body, which has a vital role in metabolic functions. The
non‐steroidal anti‐inflammatory drug (NSAID), diclofenac causes hepato‐renal toxicity and …
non‐steroidal anti‐inflammatory drug (NSAID), diclofenac causes hepato‐renal toxicity and …
Antioxidant and hepatoprotective efficiency of selenium nanoparticles against acetaminophen-induced hepatic damage
Overdoses of acetaminophen (APAP), a famous and widely used drug, may have
hepatotoxic effects. Nanoscience is a novel scientific discipline that provides specific tools …
hepatotoxic effects. Nanoscience is a novel scientific discipline that provides specific tools …
Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity
Mitochondrial biogenesis (MB) is an adaptive response to maintain metabolic homeostasis
after mitochondrial dysfunction. Induction of MB during APAP hepatotoxicity has not been …
after mitochondrial dysfunction. Induction of MB during APAP hepatotoxicity has not been …
Caspase-mediated anti-apoptotic effect of ginsenoside Rg5, a main rare ginsenoside, on acetaminophen-induced hepatotoxicity in mice
Z Wang, J Hu, M Yan, J Xing, W Liu… - Journal of agricultural and …, 2017 - ACS Publications
Frequent overdose of acetaminophen (APAP) is one of the most common and important
incentives of acute hepatotoxicity. Prior to this work, our research group confirmed that black …
incentives of acute hepatotoxicity. Prior to this work, our research group confirmed that black …
Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury
JN Hu, Z Liu, Z Wang, XD Li, LX Zhang, W Li, YP Wang - Molecules, 2017 - mdpi.com
Background: Frequent overdosing of acetaminophen (APAP) has become the major cause
of acute liver injury (ALI). The present study aimed to evaluate the potential hepatoprotective …
of acute liver injury (ALI). The present study aimed to evaluate the potential hepatoprotective …
Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies
L Cao, A Kwara, DJ Greenblatt - Journal of Pharmacy and …, 2017 - academic.oup.com
Objectives Excessive exposure to acetaminophen (APAP, paracetamol) can cause liver
injury through formation of a reactive metabolite that depletes hepatic glutathione and …
injury through formation of a reactive metabolite that depletes hepatic glutathione and …
[PDF][PDF] Regulatory T‐cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis
Imbalance between T regulatory (Treg) and T effector (Teff) cells is likely to contribute to the
induction and perpetuation of liver damage in autoimmune hepatitis (AIH) and autoimmune …
induction and perpetuation of liver damage in autoimmune hepatitis (AIH) and autoimmune …
Sestrin2 protects against acetaminophen-induced liver injury
SJ Kim, KM Kim, JH Yang, SS Cho, JY Kim… - Chemico-biological …, 2017 - Elsevier
Acetaminophen (APAP) overdose accounts for half of the cases of acute liver failure
worldwide. We previously reported that Sestrin2 (Sesn2) protects against d-galactosamine …
worldwide. We previously reported that Sestrin2 (Sesn2) protects against d-galactosamine …