Background Liver inflammation or hepatitis is a result of pluripotent interactions of cell death
molecules, cytokines, chemokines and the resident immune cells collectively called as …

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive mitochondrial
oxidant stress. However, its importance as a drug target has not been clarified. To …

The liver is an important organ of the body, which has a vital role in metabolic functions. The
non‐steroidal anti‐inflammatory drug (NSAID), diclofenac causes hepato‐renal toxicity and …

Overdoses of acetaminophen (APAP), a famous and widely used drug, may have
hepatotoxic effects. Nanoscience is a novel scientific discipline that provides specific tools …

Mitochondrial biogenesis (MB) is an adaptive response to maintain metabolic homeostasis
after mitochondrial dysfunction. Induction of MB during APAP hepatotoxicity has not been …

Frequent overdose of acetaminophen (APAP) is one of the most common and important
incentives of acute hepatotoxicity. Prior to this work, our research group confirmed that black …

Background: Frequent overdosing of acetaminophen (APAP) has become the major cause
of acute liver injury (ALI). The present study aimed to evaluate the potential hepatoprotective …

Objectives Excessive exposure to acetaminophen (APAP, paracetamol) can cause liver
injury through formation of a reactive metabolite that depletes hepatic glutathione and …

Imbalance between T regulatory (Treg) and T effector (Teff) cells is likely to contribute to the
induction and perpetuation of liver damage in autoimmune hepatitis (AIH) and autoimmune …

Acetaminophen (APAP) overdose accounts for half of the cases of acute liver failure
worldwide. We previously reported that Sestrin2 (Sesn2) protects against d-galactosamine …