Memory B cells are major targets for effective immunotherapy in relapsing multiple sclerosis
Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …
Hello from the other side: how autoantibodies circumvent the blood–brain barrier in autoimmune encephalitis
MP Platt, D Agalliu, T Cutforth - Frontiers in immunology, 2017 - frontiersin.org
Antibodies against neuronal receptors and synaptic proteins are associated with
autoimmune encephalitides (AE) that produce movement and psychiatric disorders. In order …
autoimmune encephalitides (AE) that produce movement and psychiatric disorders. In order …
Targeting B cells in relapsing–remitting multiple sclerosis: from pathophysiology to optimal clinical management
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that is caused by an
autoimmune response against central nervous system (CNS) structures. Traditionally …
autoimmune response against central nervous system (CNS) structures. Traditionally …
[HTML][HTML] ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis
RFW Hawkins, A Patenaude, A Dumas, R Jain… - JCI insight, 2017 - ncbi.nlm.nih.gov
Neutrophils contribute to demyelinating autoimmune diseases, yet their phenotype and
functions have been elusive to date. Here, we demonstrate that ICAM1 surface expression …
functions have been elusive to date. Here, we demonstrate that ICAM1 surface expression …
Epstein–Barr virus and multiple sclerosis: Updating Pender's hypothesis
M Laurence, J Benito-León - Multiple sclerosis and related disorders, 2017 - Elsevier
Substantial epidemiological evidence supports the involvement of the Epstein–Barr virus
(EBV) in multiple sclerosis (MS). Mechanisms through which EBV may increase MS risk are …
(EBV) in multiple sclerosis (MS). Mechanisms through which EBV may increase MS risk are …
Central modulation of neuroinflammation by neuropeptides and energy‐sensing hormones during obesity
R Maldonado-Ruiz, L Fuentes-Mera… - BioMed research …, 2017 - Wiley Online Library
Central nervous system (CNS) senses energy homeostasis by integrating both peripheral
and autonomic signals and responding to them by neurotransmitters and neuropeptides …
and autonomic signals and responding to them by neurotransmitters and neuropeptides …
[PDF][PDF] B-cell depletion–a frontier in monoclonal antibodies for multiple sclerosis
PA Calabresi - N Engl J Med, 2017 - msnz.org.nz
Multiple sclerosis is a disabling autoimmune disease in which immune cells target central
nervous system (CNS) antigens, leading to demyelination, glial activation, and subsequent …
nervous system (CNS) antigens, leading to demyelination, glial activation, and subsequent …
Cerebrospinal fluid B cells and disease progression in multiple sclerosis-A longitudinal prospective study
S Wurth, B Kuenz, G Bsteh, R Ehling, F Di Pauli… - PLoS …, 2017 - journals.plos.org
Background There is evidence that B cells play an important role in disease pathology of
multiple sclerosis (MS). The aim of this prospective observational study was to determine the …
multiple sclerosis (MS). The aim of this prospective observational study was to determine the …
Spatiotemporal resolution of spinal meningeal and parenchymal inflammation during experimental autoimmune encephalomyelitis
B Shrestha, X Jiang, S Ge, D Paul, P Chianchiano… - Neurobiology of …, 2017 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of
C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG 35–55), is a …
C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG 35–55), is a …
Activated GL7+ B cells are maintained within the inflamed CNS in the absence of follicle formation during viral encephalomyelitis
KD DiSano, SA Stohlman, CC Bergmann - Brain, behavior, and immunity, 2017 - Elsevier
Central nervous system (CNS) inflammation associated with viral infection and autoimmune
disease results in the accumulation of B cells in various differentiation stages. However, the …
disease results in the accumulation of B cells in various differentiation stages. However, the …