Chemokines from a structural perspective

MC Miller, KH Mayo - International journal of molecular sciences, 2017 - mdpi.com
Chemokines are a family of small, highly conserved cytokines that mediate various
biological processes, including chemotaxis, hematopoiesis, and angiogenesis, and that …

Glycosaminoglycan interactions with chemokines add complexity to a complex system

AEI Proudfoot, Z Johnson, P Bonvin, TM Handel - Pharmaceuticals, 2017 - mdpi.com
Chemokines have two types of interactions that function cooperatively to control cell
migration. Chemokine receptors on migrating cells integrate signals initiated upon …

ITIM receptors: more than just inhibitors of platelet activation

CH Coxon, MJ Geer, YA Senis - Blood, The Journal of the …, 2017 - ashpublications.org
Since their discovery, immunoreceptor tyrosine-based inhibition motif (ITIM)-containing
receptors have been shown to inhibit signaling from immunoreceptor tyrosine-based …

Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization

DP Dyer, E Migliorini, CL Salanga… - Open …, 2017 - royalsocietypublishing.org
Chemokines control the migration of cells in normal physiological processes and in the
context of disease such as inflammation, autoimmunity and cancer. Two major interactions …

Modulation of amyloid assembly by glycosaminoglycans: from mechanism to biological significance

N Quittot, M Sebastiao… - Biochemistry and Cell …, 2017 - cdnsciencepub.com
Glycosaminoglycans (GAGs) are long and unbranched polysaccharides that are abundant
in the extracellular matrix and basement membrane of multicellular organisms. These linear …

Pro-angiogenic effect of RANTES-loaded polysaccharide-based microparticles for a mouse ischemia therapy

N Suffee, C Le Visage, H Hlawaty, R Aid-Launais… - Scientific Reports, 2017 - nature.com
Peripheral arterial disease results from the chronic obstruction of arteries leading to critical
hindlimb ischemia. The aim was to develop a new therapeutic strategy of revascularization …

Two glycosaminoglycan-binding domains of the mouse cytomegalovirus-encoded chemokine MCK-2 are critical for oligomerization of the full-length protein

SM Pontejo, PM Murphy - Journal of Biological Chemistry, 2017 - ASBMB
Chemokines are essential for antimicrobial host defenses and tissue repair. Herpesviruses
and poxviruses also encode chemokines, copied from their hosts and repurposed for …

Chemokines and Chemotaxis

O Yoshie, K Matsushima - Inflammation: From Molecular and …, 2017 - Wiley Online Library
This chapter provides an overview of the chemokine superfamily with a particular focus on
their role in the immune system. Concerning the chemokine receptor nomenclature, it was …

Cysteine proteases of hookworm Necator Americanus as virulence factors and implications for future drug design: A bioinformatics-based study

A Banerjee, R Abagyan - bioRxiv, 2017 - biorxiv.org
Abstract Human hookworm Necator Americanus causes iron deficiency anemia, as the
parasite ingests blood from the gastrointestinal tract of its human host. The virulence factors …

[PDF][PDF] DOCTOR OF PHILOSOPHY (PhD)

VG Motos - 2017 - elib.tiho-hannover.de
The Herpesviridae family is formed by enveloped viruses containing double stranded DNA
(dsDNA) genome with the ability to establish latency in specific cell types. Members of this …