Invasive fungal infections continue to appear in record numbers as the
immunocompromised population of the world increases, owing partially to the increased …

The prevention, diagnosis, and management of infectious disease in transplantation are
major contributors to improved outcomes in organ transplantation. The risk of serious …

Abstract The Infectious Diseases Society of America (IDSA) Standards and Practice
Guidelines Committee collaborated with partner organizations to convene a panel of 10 …

Antifungal resistance represents a major clinical challenge to clinicians responsible for
treating invasive fungal infections due to the limited arsenal of systemically available …

The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …

Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …

Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum
concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 …

Aspergillus fumigatus remains the most common species in all pulmonary syndromes,
followed by Aspergillus flavus which is a common cause of allergic rhinosinusitis …

Critically ill patients and patients with haematological cancer are HIV-negative populations
at high risk of invasive fungal infections. In intensive-care units, candidaemia and intra …

Over the coming years, accelerating progress against cancer will be associated with an
increased number of patients who require life-sustaining therapies for infectious or toxic …