Understanding and applying pharmacometric modelling and simulation in clinical practice and research
JF Standing - British journal of clinical pharmacology, 2017 - Wiley Online Library
Understanding the dose–concentration–effect relationship is a fundamental component of
clinical pharmacology. Interpreting data arising from observations of this relationship …
clinical pharmacology. Interpreting data arising from observations of this relationship …
Model evaluation of continuous data pharmacometric models: metrics and graphics
THT Nguyen, MS Mouksassi, N Holford… - CPT …, 2017 - Wiley Online Library
This article represents the first in a series of tutorials on model evaluation in nonlinear mixed
effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model …
effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model …
Clinical pharmacokinetics and pharmacodynamics of febuxostat
B Kamel, GG Graham, KM Williams, KD Pile… - Clinical …, 2017 - Springer
Febuxostat is a xanthine oxidoreductase inhibitor that has been developed to treat chronic
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …
Therapeutic drug monitoring of biopharmaceuticals may benefit from pharmacokinetic and pharmacokinetic–pharmacodynamic modeling
C Passot, MF Pouw, D Mulleman… - Therapeutic drug …, 2017 - journals.lww.com
Biopharmaceuticals, especially monoclonal antibodies, have been increasingly used to treat
several chronic inflammatory diseases. Due to the complexity of their pharmacokinetics and …
several chronic inflammatory diseases. Due to the complexity of their pharmacokinetics and …
From an indirect response pharmacodynamic model towards a secondary signal model of dose-response relationship between exercise training and physical …
T Busso - Scientific Reports, 2017 - nature.com
The aim of this study was to test the suitability of using indirect responses for modeling the
effects of physical training on performance. We formulated four different models assuming …
effects of physical training on performance. We formulated four different models assuming …
Is there potential for therapeutic drug monitoring of biologic agents in rheumatoid arthritis?
The use of biologics has significantly changed the management of rheumatoid arthritis over
the last decade, becoming the cornerstone treatment for many patients. The current …
the last decade, becoming the cornerstone treatment for many patients. The current …
Absorption of bupivacaine after administration of a lozenge as topical treatment for pain from oral mucositis
S Mogensen, E Sverrisdóttir… - Basic & clinical …, 2017 - Wiley Online Library
The aim was to investigate systemic exposure after administration of a novel bupivacaine
lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) …
lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) …
Predicting QRS and PR interval prolongations in humans using nonclinical data
L Bergenholm, J Parkinson, J Mettetal… - British Journal of …, 2017 - Wiley Online Library
Background and Purpose Risk of cardiac conduction slowing (QRS/PR prolongations) is
assessed prior to clinical trials using in vitro and in vivo studies. Understanding the …
assessed prior to clinical trials using in vitro and in vivo studies. Understanding the …
A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679
JR Gosset, K Beaumont, T Matsuura… - European Journal of …, 2017 - Elsevier
PF-05105679 is a moderately potent TRPM8 blocker which has been evaluated for the
treatment of cold pain sensitivity. The TRPM8 channel is responsible for the sensation of …
treatment of cold pain sensitivity. The TRPM8 channel is responsible for the sensation of …
[HTML][HTML] Physiologically based pharmacokinetic modeling for predicting irinotecan exposure in human body
Y Fan, N Mansoor, T Ahmad, RA Khan, M Czejka… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer is the third leading cause of cancer-related deaths in the United States.
Treatment of colorectal cancer remains a challenge to clinicians as well as drug developers …
Treatment of colorectal cancer remains a challenge to clinicians as well as drug developers …