Understanding the dose–concentration–effect relationship is a fundamental component of
clinical pharmacology. Interpreting data arising from observations of this relationship …

This article represents the first in a series of tutorials on model evaluation in nonlinear mixed
effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model …

Febuxostat is a xanthine oxidoreductase inhibitor that has been developed to treat chronic
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …

Biopharmaceuticals, especially monoclonal antibodies, have been increasingly used to treat
several chronic inflammatory diseases. Due to the complexity of their pharmacokinetics and …

The aim of this study was to test the suitability of using indirect responses for modeling the
effects of physical training on performance. We formulated four different models assuming …

The use of biologics has significantly changed the management of rheumatoid arthritis over
the last decade, becoming the cornerstone treatment for many patients. The current …

The aim was to investigate systemic exposure after administration of a novel bupivacaine
lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) …

Background and Purpose Risk of cardiac conduction slowing (QRS/PR prolongations) is
assessed prior to clinical trials using in vitro and in vivo studies. Understanding the …

PF-05105679 is a moderately potent TRPM8 blocker which has been evaluated for the
treatment of cold pain sensitivity. The TRPM8 channel is responsible for the sensation of …

Colorectal cancer is the third leading cause of cancer-related deaths in the United States.
Treatment of colorectal cancer remains a challenge to clinicians as well as drug developers …