The global problem of antifungal resistance: prevalence, mechanisms, and management

DS Perlin, R Rautemaa-Richardson… - The Lancet infectious …, 2017 - thelancet.com
All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …

Essential oils and antifungal activity

F Nazzaro, F Fratianni, R Coppola, V De Feo - Pharmaceuticals, 2017 - mdpi.com
Since ancient times, folk medicine and agro-food science have benefitted from the use of
plant derivatives, such as essential oils, to combat different diseases, as well as to preserve …

Candida albicans cell-type switching and functional plasticity in the mammalian host

SM Noble, BA Gianetti, JN Witchley - Nature Reviews Microbiology, 2017 - nature.com
Candida albicans is a ubiquitous commensal of the mammalian microbiome and the most
prevalent fungal pathogen of humans. A cell-type transition between yeast and hyphal …

Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

Fungal biofilms and polymicrobial diseases

CB Costa-Orlandi, JCO Sardi, NS Pitangui… - Journal of Fungi, 2017 - mdpi.com
Biofilm formation is an important virulence factor for pathogenic fungi. Both yeasts and
filamentous fungi can adhere to biotic and abiotic surfaces, developing into highly organized …

Agriculturally important microbial biofilms: present status and future prospects

K Velmourougane, R Prasanna… - Journal of basic …, 2017 - Wiley Online Library
Microbial biofilms are a fascinating subject, due to their significant roles in the environment,
industry, and health. Advances in biochemical and molecular techniques have helped in …

The Candida albicans Biofilm Matrix: Composition, Structure and Function

CG Pierce, T Vila, JA Romo, D Montelongo-Jauregui… - Journal of Fungi, 2017 - mdpi.com
A majority of infections caused by Candida albicans—the most frequent fungal pathogen—
are associated with biofilm formation. A salient feature of C. albicans biofilms is the presence …

Thymus vulgaris L. extract has antimicrobial and anti-inflammatory effects in the absence of cytotoxicity and genotoxicity

JR de Oliveira, D de Jesus Viegas, APR Martins… - Archives of oral …, 2017 - Elsevier
Objectives This study evaluated the biological effects of the T. vulgaris L. extract., such as
antimicrobial activity on planktonic cultures and mono-and polymicrobial biofilms …

Screening the Pathogen Box for identification of Candida albicans biofilm inhibitors

T Vila, JL Lopez-Ribot - Antimicrobial Agents and Chemotherapy, 2017 - Am Soc Microbiol
Candida albicans remains the main causative agent of candidiasis, one of the most frequent
nosocomial infections, with unacceptably high mortality rates. Biofilm formation is a major …

Antimicrobial peptides as a strategy to combat fungal biofilms

N Delattin, K De Brucker, K De Cremer… - Current Topics in …, 2017 - ingentaconnect.com
Invasive fungal infections caused by opportunistic fungal pathogens are associated with
high mortality rates, mainly due to the occurrence of genotypic and/or phenotypic resistance …