Strategies utilizing Toll-like receptor 4 (TLR4) agonists for treatment of cancer, infectious
diseases, and other targets report promising results. Potent TLR4 antagonists are also …

Highlights•The glycolipid Lipid A is the conserved, amphipathic moiety of LPS.•Lipid A binds
to certain Toll like receptors and caspases with high affinity.•Bacteria alter their Lipid A …

Mass spectrometry imaging (MSI) was used to elucidate host lipids involved in the
inflammatory signaling pathway generated at the host–pathogen interface during a septic …

Structural modification of lipid A, the lipid anchor of LPS, is one of the strategies used by
Gram-negative bacteria to evade host innate immunity. Francisella tularensis is a human …

Background The work was undertaken to expand the tools available for researching
Burkholderia pseudomallei (Bp), the etiological agent of the tropical disease melioidosis …

Francisella tularensis, a gram–negative facultative intracellular bacterial pathogen, is the
causative agent of tularemia and able to infect many mammalian species, including humans …

Xylella fastidiosa causes Pierce's disease (PD) on grapevines, leading to significant
economic losses in grape and wine production. To further our understanding of X. fastidiosa …

Francisella novicida is a gram-negative pathogen commonly used to study infections by the
potential bioterrorism agent, Francisella tularensis. The Francisella lipid A structure has …

Francisella tularensis is an intracellular human pathogen able to infect and replicate within
phagocytic cells without triggering any immune response, in part via the production of an …

Francisella tularensis est une bactérie intracellulaire à Gram négatif et l'un des agents les
plus infectieux connu à l'heure actuelle, en particulier par voie respiratoire. L'inhalation …