Wnt signaling in cardiovascular disease: opportunities and challenges
A Gay, DA Towler - Current opinion in lipidology, 2017 - journals.lww.com
Components of the Wnt signaling cascade represent novel targets for pharmacological
intervention in cardiometabolic disease. Conversely, strategies targeting the Wnt signaling …
intervention in cardiometabolic disease. Conversely, strategies targeting the Wnt signaling …
Wnt signaling in the vessel wall
L Badimon, M Borrell-Pages - Current Opinion in Hematology, 2017 - journals.lww.com
Many of the clinical trials developed in the last decade to reduce atherosclerosis and
cardiovascular diseases have been futile or have failed possibly because of a poor …
cardiovascular diseases have been futile or have failed possibly because of a poor …
[HTML][HTML] Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress
M Di, L Wang, M Li, Y Zhang, X Liu, R Zeng… - Cell death & …, 2017 - nature.com
Several clinical studies reported that Dickkopf1 (DKK1) plasma levels are correlated with
atherosclerosis. However, the impact of DKK1 on the formation and vulnerability of …
atherosclerosis. However, the impact of DKK1 on the formation and vulnerability of …
A cytokine-like protein dickkopf-related protein 3 is atheroprotective
B Yu, S Kiechl, D Qi, X Wang, Y Song, S Weger… - Circulation, 2017 - Am Heart Assoc
Background: Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the
regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is …
regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is …
[HTML][HTML] Circulating levels of sclerostin but not DKK1 associate with laboratory parameters of CKD-MBD
GJ Behets, L Viaene, B Meijers, F Blocki… - PLOS …, 2017 - journals.plos.org
Introduction Mounting evidence indicates that a disturbed Wnt–β-catenin signaling may be
involved in the pathogenesis of chronic kidney disease-mineral and bone and mineral …
involved in the pathogenesis of chronic kidney disease-mineral and bone and mineral …
3D structure of DKK1 indicates its involvement in both canonical and non-canonical Wnt pathways
Abstract Dikkoppf-1 (DKK1) is an antagonist of the canonical Wnt signaling pathway. The
importance of DKK1 as a diagnostic and therapeutic agent in a wide range of diseases …
importance of DKK1 as a diagnostic and therapeutic agent in a wide range of diseases …
[HTML][HTML] TEMs but not DKK1 could serve as complementary biomarkers for AFP in diagnosing AFP-negative hepatocellular carcinoma
L Mao, Y Wang, D Wang, G Han, S Fu, J Wang - PLoS One, 2017 - journals.plos.org
Background & aims Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is
prevalent worldwide. Despite its limitations, serum alpha-fetoprotein (AFP) remains the most …
prevalent worldwide. Despite its limitations, serum alpha-fetoprotein (AFP) remains the most …
Small interfering RNA targeting Dickkopf-1 contributes to neuroprotection after intracerebral hemorrhage in rats
Z Li, X Chen, X Zhang, X Ren, X Chen, J Cao… - Journal of Molecular …, 2017 - Springer
Abstract Excessive Dickkopf-1 (Dkk-1) plays a vital role in secondary brain injury following
ischemic stroke and psychotic disease. However, it is unclear whether an increased …
ischemic stroke and psychotic disease. However, it is unclear whether an increased …
Myocardial perfusion in rheumatoid arthritis patients: associations with traditional risk factors and novel biomarkers
M Bernardes, TS Vieira, MJ Martins… - BioMed Research …, 2017 - Wiley Online Library
Introduction. Cardiovascular (CV) diseases are a major cause of death in rheumatoid
arthritis (RA) patients. Novel biomarkers [B‐type natriuretic peptide (BNP); osteoprotegerin …
arthritis (RA) patients. Novel biomarkers [B‐type natriuretic peptide (BNP); osteoprotegerin …
Association of circulating Wnt antagonists with severe abdominal aortic calcification in elderly women
WA Touw, T Ueland, J Bollerslev… - Journal of the …, 2017 - academic.oup.com
Context: There is great interest in the biology of vascular calcification. Wnt/β-catenin
signaling is an important mediator of mineralization and may play a role in vascular …
signaling is an important mediator of mineralization and may play a role in vascular …