High plasma levels of fatty acids occur in a variety of metabolic diseases. Cellular effects of
fatty acid overload resulting in negative cellular responses (lipotoxicity) are often studied in …

Insulin resistance (IR), a key component of the metabolic syndrome, precedes the
development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological …

Clinical trials have extensively failed to find effective treatments for Alzheimer's disease (AD)
so far. Even after decades of AD research, there are still limited options for treating …

Dietary fats can modulate brain function. How free fatty acids (FFAs) alter hypothalamic pro-
opiomelanocortin (POMC) neurons remain undefined. The saturated FFA, palmitate …

While cognitive decline and memory loss are the major clinical manifestations of Alzheimer's
disease (AD), they are now recognized as late features of the disease. Recent failures in …

Aim Glucagon‐like peptide‐1 is an incretin hormone secreted by the intestinal L‐cell with a
circadian rhythm that parallels expression of the core clock gene, Bmal1. Although feeding …

Astrocytes participate in both physiological and pathophysiological responses to metabolic
and nutrient signals. Although most studies have focused on the astrocytic response to …

Insulin resistance, a pathophysiology of type 2 diabetes, is associated with obesity.
Lipotoxicity in obesity leads to the dysfunction and death of pancreatic β-cells and …

Endothelial cell senescence is regarded as a vital characteristic of cardiovascular diseases.
Elevated palmitate (PA) is an independent risk factor of cardiovascular diseases, but its role …

Yellow-soybean-leaf extract includes kaempferol glycosides and pheophorbides that reduce
obesity and plasma glucose levels. This study researched the molecular mechanisms …